Neurology Outcomes Report


2018 Report on Clinical & Scientific Innovations in Neurology & Neurosurgery

Innovations at a Glance

  • One of 28 sites in a phase 2 clinical trial showing that the investigational anti-inflammatory drug ibudilast was superior to placebo in slowing the progression of brain atrophy in multiple sclerosis

    colorful brain xray
  • Conducted the first-ever dose escalation study using convection-enhanced delivery for diffuse intrinsic pontine glioma to bypass the blood-brain barrier and administer a drug directly to a brain stem tumor site

  • Epigenome-wide study uncovers large-scale changes throughout the epigenome of the human Alzheimer’s disease brain, revealing that tau-induced alterations of chromatin structure are much more profound then the changes that are attributable to amyloid pathology.

  • Investigated venous sinus stenting in patients with idiopathic intracranial hypertension, showing for the first time a quantitative reduction in intracranial pressure

    human brain
  • One of 25 clinical sites across the country for NeuroNEXT, an NIH-Network for Excellence in Neuroscience Clinical Trials created to expand capabilities for studies of promising new therapies for neurological diseases

  • Created ALS Families Project to study relatives of individuals with amyotrophic lateral sclerosis who carry the same mutation to understand the earliest steps in its onset and how and why it develops

    focused ultrasound of the brain
  • Treated the first patient in a multicenter pivotal trial using focused ultrasound to address the major motor symptoms of Parkinson’s disease

    ultrasound machinary
  • Identified the cell types and locations of origin of subependymomas, helping to improve diagnosis and treatment of patients with this rare disease

  • Pioneered a minimally invasive posterior lumbar interbody fusion technique with cortical bone trajectory screws that are biomechanically stronger than pedicle screws, requires a smaller incision, and results in less muscle damage

    small incision for pedicle screws