Stem Cell Transplantation
Kinder, gentler bone marrow transplantation
NewYork-Presbyterian Morgan Stanley Children's Hospital has one of the oldest stem cell and bone marrow transplantation (BMT) programs in the nation, offering this treatment to children with cancerous and non-cancerous conditions. Some patients can have a novel "reduced-intensity" approach to stem cell transplantation, where we give low-dose chemotherapy plus immune therapy to allow the donor's cells to grow while minimizing side effects.
- National Excellence: With one of the largest BMT programs in the nation, we offer autologous and allogeneic stem cell transplantations to treat children and adolescents with certain cancers and non-cancerous conditions. Our stem cell transplant program is accredited by the Foundation for the Accreditation of Cellular Therapy (FACT) and the National Marrow Donor Program (NMDP) for autologous (self), allogeneic (donated), and umbilical cord blood transplantations.
- Bone Marrow Transplants from Unrelated Donors: We have a very active program in "alternate donor" bone marrow transplantation, such as bone marrow from unrelated donors or donations from umbilical cord blood units. Our Unrelated Adult Donor (Non-Cord) Stem Cell Transplant program is approved by the NMDP to perform unrelated adult donor stem cell transplants. Our specialists are also renowned for their pioneering work and expertise in umbilical cord blood transplantation. Umbilical cord blood transplants have been used as an alternative source of stem cells since 1988 and can be an excellent source of stem cells for some patients.
- Treatment of Lymphohistiocytosis: We have special expertise in the use of stem cell transplantation to treat hemophagocytic lymphohistiocytosis — a disorder in which the immune system produces too many activated immune cells called T cells, natural killer cells, B cells, and macrophages (histiocytes).
- Sickle Cell Transplant Program: We have one of the largest and most successful transplant programs in the country for sickle cell disease.
- Exceptional Support: We understand that a stem cell transplant is a lengthy process and that your child will need to be in the hospital for some time. We offer support, activities, education, and guidance during your child's time with us, as well as afterward, when it's time to go home. The Center for Comprehensive Wellness offers a full range of supportive care and integrative health services for your child, you, and other family members.
- Novel Therapies for Post-Transplant Complications: We excel in the use of novel treatments for acute and chronic graft-versus-host disease (GVHD), a potential complication of transplantation in which cells from the donor attack tissues of the recipient. One of these methods is extracorporeal photophoresis, a technique in which we remove white blood cells from the patient's bloodstream, expose them to a drug that makes the cells sensitive to light, and then treat them with ultraviolet radiation to kill large numbers of the white blood cells that may cause GVHD. Another innovative method we use to prevent GVHD is CD34-selected stem cell transplantation, where we enrich the stem cell product with a certain number of T cells that regulate growth of the donated cells, but at the same time do not cause GVHD.