Advances in Oncology

Our oncology teams are finding breakthrough treatments to advance cancer care.

As one of 50 NCI designated comprehensive cancer centers in the country, our oncology program is helping patients beat the odds with comprehensive, multi-disciplinary care leveraging the latest in technology and novel therapies.

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2022 Innovations in Review


In this 2022 review, read about NewYork-Presbyterian’s clinical and scientific advances in early cancer detection strategies and the acceleration of personalized therapeutics to achieve the best possible outcomes.

Micrograph of diffuse large B-cell lymphoma

New Approaches Discovered to Enhance Immunotherapy to Treat Aggressive Form of B-Cell Lymphoma

Columbia oncologist finds that YF2, a first-in-class drug, modulates immune evasion and enhances the effects of immune checkpoint blockade in diffuse large B-cell lymphoma

MRI scans in both the axial and sagittal planes

A Breakthrough Radiotherapy Technique for Early Stage Breast Cancer Patients

NewYork-Presbyterian/Weill Cornell Medicine have developed a technique to treat early breast cancers with MRI-guided prone breast radiotherapy

image of Scientist pipetting sample into a vial for DNA testing

Advancing the Early Detection of Pancreatic Cancer

At Columbia, Dr. Anil Rustgi presents insights into the current state of genetic testing, screening and surveillance with a goal to diagnose pancreatic cancer at a more treatable stage.

Images of uterine sarcoma and scalp lesion

Targeted Therapy Shows Promise for Aggressive Uterine Sarcoma

Columbia oncologists led a phase 2 clinical trial demonstrating the potential of olaparib combined with chemotherapy to treat patients with uterine leiomyosarcoma, a rare and deadly form of uterine cancer.

image of Triple-negative breast cancer cell

Reason for Optimism: Advancing Therapy for Triple-Negative Breast Cancer

Columbia breast oncologist co-chairs Expert Panel to develop ASCO Guideline Rapid Recommendation Update on adding immunotherapy to neoadjuvant chemotherapy to treat TNBC.

image of Non-solid nodule on CT screening for lung cancer

Tumor Microenvironment of Lung Cancer: What Lies Beneath?

Weill Cornell Medicine investigators examine the role of the tumor microenvironment in the progression of precancerous non-solid nodules that appear on CT to invasive lung adenocarcinoma.

CT Scan machine

A Paradigm Shift in Radiation Treatment Planning

Columbia radiation oncologists are using a new radiation delivery system that leverages artificial intelligence to create a personalized plan in minutes and offers better cancer control while further reducing radiation side effects.

medical concept 3D Illustration of Human Lymph Nodes System Anatomy

How Melanoma Prepares Lymph Nodes for Metastases

Weill Cornell Medicine cancer researchers uncover protein released in exosomes secreted by melanoma cells that leads to lymphangiogenesis.

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Promising Treatment Emerges for Recurrent Glioblastoma

Columbia neuro-oncologist leads international phase 2 trial of selinexor, the first of a new class of anticancer drugs.

image of Dr. Nasser Altorki and Dr. Silvia Formenti

Lung Cancer: Testing a Novel Protocol

Combining immune checkpoint blockade and radiotherapy preoperatively is associated with a significant enhancement of major pathological response in the treatment of early-stage non-small-cell lung cancer.

image of Diffuse large B-cell lymphoma

New Understanding of B-Cell Cancers

Weill Cornell Medicine and Columbia University faculty at NewYork-Presbyterian Hospital have uncovered new information on the roles of the microenvironment and genomic architecture underlying the development and progression of B-cell and other malignancies.

image of DNA strand and cancer cell oncology research concept 3D rendering

Novel Approaches to Personalizing Cancer Therapy

Scientists at Columbia University and Weill Cornell Medicine are applying contemporary methods of data analysis to generate algorithms that narrow the number of genetic drivers involved in cancer development.

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Accelerating Therapies for Challenging Blood Disorders

From studies in the laboratory to evaluating therapeutics in clinical trials, faculty at the NCI-designated Herbert Irving Comprehensive Cancer Center at Columbia University and the Weill Cornell Medicine Meyer Cancer Center in partnership with NewYork-Presbyterian are addressing the treatment challenges of blood disorders.

x-ray images of prostate cancer

Prolonging Life for Men with Prostate Cancer

Extending survival was the focus of a recent multinational phase 3 clinical trial of a combination therapy for men with nonmetastatic, castration-resistant prostate cancer. Led by Weill Cornell Medicine Oncology, the study provides evidence that adding androgen-receptor inhibitors to current therapies delays metastasis and improves survival.

digital medical illustration of lung cancer in the lungs

Non-Small Cell Lung Cancer: A New Combination for Neoadjuvant Therapy

A novel trial of chemotherapy combined with a PD-L1 inhibitor administered preoperatively in patients with resectable non-small cell lung cancer has had impressive results, raising expectations among oncologists and surgeons that they may soon have a new therapeutic strategy to offer patients with this life-threatening disease.

vector image of lymphomagenesis

Novel Research Advancing Cancer Care and Treatment

Studies by Columbia University and Weill Cornell Medicine faculty are making headlines in oncology research, providing promising evidence for new therapies and better understanding of the origins of blood and solid tumor cancers.

photomicrograph of a diffuse large B-cell lymphoma (DLBCL)

Extending the Boundaries of Cancer Care

NewYork-Presbyterian/Weill Cornell Medical Center is taking cancer care to the next level. Our healthcare providers are available to treat patients with advanced treatments like CAR T-cell therapy and provide access to clinical trials of promising new and innovative therapies.

image of Fibrosarcoma, light micrograph, photo under microscope

Exceptional Expertise in Rare Cancers

Combined rare cancers account for 50% of all cancer diagnoses. Researchers at the Herbert Irving Comprehensive Cancer Center at NewYork-Presbyterian/Columbia University Irving Medical Center are leading initiatives in rare cancers for cooperative study groups.

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Investigating Immunotherapy Approaches in Genitourinary Oncology

Dr. Charles G. Drake initiated a cutting-edge trial in which androgen deprivation therapy is combined with a drug aimed at preventing suppressive myeloid cells from entering the prostate tumor microenvironment at the time of therapy.

image of Dr. Markus Y. Mapara

A New Take on BMT and Cellular Therapies

As the Adult Blood and Marrow Transplant Program at NewYork-Presbyterian/Columbia continues to expand, clinicians are investigating new treatment approaches ranging from autologous to allogeneic and haplo-identical transplantation.

image of Vitamin C, DHA conversion, and transport in KRAS and BRAF mutated cells

Confronting Solid Tumors: Vitamin C Takes on the KRAS Gene

With a multimillion dollar grant, investigators at NewYork-Presbyterian/Weill Cornell are conducting human trials to confirm that high doses of vitamin C impairs the growth of colorectal tumors.

image of Dr. Eleni Andreopoulou

Neoadjuvant Therapy in Breast Cancer: A New Raison D’être

In the past 50 years, use of neoadjuvant chemotherapy for breast cancer has evolved. Today, clinicians at NewYork-Presbyterian are using neoadjuvant therapy to tackle residual tumor.

image of cryotherapy to freeze a tumor

Targeting Early Breast Cancers with Ablation Therapies

Surgeons at NewYork-Presbyterian/Columbia are turning up the heat (or cold as the case may be) on early-stage breast cancer tumors with the use of ablation therapies.

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Spring/Summer 2016