Advances in Oncology

Our oncology teams are finding breakthrough treatments to advance cancer care.

As one of 50 NCI designated comprehensive cancer centers in the country, our oncology program is helping patients beat the odds with comprehensive, multi-disciplinary care leveraging the latest in technology and novel therapies.

digital vector illustration of prostate cancer
Oncology, Urology

Novel Combination Therapy Targets Advanced Prostate Cancer

Columbia medical oncologist leads clinical trial to determine safety of combining ONC-392 with Lutetium Lu 177 vipivotide tetraxetan (Pluvicto) in patients with PSMA-positive metastatic castration-resistant prostate cancer (mCRPC).

image of 2022 innovations in review cover
2022 Innovations in Review


In this 2022 review, read about NewYork-Presbyterian’s clinical and scientific advances in early cancer detection strategies and the acceleration of personalized therapeutics to achieve the best possible outcomes.

b cell Lymphoma

Targeting Treatment-Resistant Lymphoma with Promising Results

Weill Cornell Medicine oncologists explore combination therapy for treatment-resistant diffuse large B-cell lymphoma.

A multipronged therapeutic strategy
Oncology, Women's Health

Opening New Avenues in the Tumor Microenvironment to Treat “Cold” Triple Negative Breast Cancer

Weill Cornell Medicine physicians target the tumor microenvironment with combination radiation therapy and immunotherapy to treat “cold” triple negative breast cancer.

image of Dr Vasan in the lab
Oncology, Women's Health

Exploring the Role of Kinases in Breast Cancer to Find Better Drugs

Columbia oncologist leads research looking at PI3K gene mutations and role in predicting therapeutic response in patients.

Medical illustration of the bladder.
Oncology, Urology

Urologist Finds Partial Cystectomy Does Not Compromise Survival in Subset of Patients With Muscle Invasive Bladder Cancer

Columbia physician evaluates survival outcomes in patients with muscle invasive bladder cancer treated with partial or radical cystectomy.

digital illustration of lynch syndrome
GI Surgery, Oncology

Moving the Needle Toward a Vaccine for Cancers Associated with Lynch Syndrome

A Weill Cornell Medicine geneticist is harnessing RNA vaccine technology to deliver a potential vaccine for cancers associated with Lynch syndrome.

digital illustration of gastric cancer
GI Surgery, Oncology

Advancing a Promising New Targeted Treatment for Metastatic Gastric Cancer

Weill Cornell Medicine medical oncologist plays key role in advancing zolbetuximab as a treatment to extend survival in patients with metastatic, HER-2 negative gastric or gastroesophageal junction cancer.

MRI of colorectal cancer liver metastases
Gastroenterology, Oncology, Transplant

Liver Transplantation Offers a Promising Option for Colorectal Cancer Liver Metastases

Weill Cornell Medicine physicians are leading cutting-edge treatments for patients with colorectal cancer liver metastases (CRLM).

digital Illustration of lung cancer in red on blue outline of the body
Oncology, Pulmonology

Seminal Study Alters How Non-Small-Cell Lung Cancer is Treated Across the Globe

Weill Cornell Medicine thoracic surgeon shares advancing treatment approaches for non-small-cell lung cancer.

Micrograph of diffuse large B-cell lymphoma

New Approaches Discovered to Enhance Immunotherapy to Treat Aggressive Form of B-Cell Lymphoma

Columbia oncologist finds that YF2, a first-in-class drug, modulates immune evasion and enhances the effects of immune checkpoint blockade in diffuse large B-cell lymphoma

3D illustration of of squamous cell carcinoma
Oncology, Otolaryngology

NewYork-Presbyterian Characterizes Genes to Predict Risk of Tongue Cancer

A Weill Cornell Medicine head and neck surgeon shares findings from a new study using whole genome sequencing to identify biomarkers that can predict progression from dysplasia to carcinoma.

3D illustration of colorectal cancer
Gastroenterology, Oncology

NewYork-Presbyterian: Focused on Detecting and Preventing High-Risk GI Cancers

The Gastrointestinal Cancer Prevention and Genetics Program at NewYork-Presbyterian/Columbia is Leading the Way to Defeat High-Risk Familial Cancers

vector illustration of cytoreductive surgery with HIPEC
Gastroenterology, Oncology

NewYork-Presbyterian Offers Innovative Approach to Treating Cancer in the Peritoneal Cavity

Weill Cornell Medicine faculty now provide cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC)

Medical illustration showing lung cancer
Oncology, Pulmonology

Transforming Care: A Minimally Invasive Approach to Lung Biopsy

A Columbia pulmonologist is changing the paradigm of care for patients with lung nodules made possible by the emerging field of interventional pulmonology.

vector illustration of colon cancer
Gastroenterology, Oncology

A Novel Treatment for Nonmetastatic Colon Cancer Meets Major Milestone in Phase 1 Clinical Trial

Weill Cornell Medicine faculty lead Phase 1 clinical trial demonstrating that starting adjuvant chemotherapy at the time of surgery is a safe and feasible approach to treating colon cancer.

MRI scans in both the axial and sagittal planes

A Breakthrough Radiotherapy Technique for Early Stage Breast Cancer Patients

NewYork-Presbyterian/Weill Cornell Medicine have developed a technique to treat early breast cancers with MRI-guided prone breast radiotherapy

digital illustration vector of the human respiratory system lungs anatomy
Gastroenterology, Oncology

The Role of Body Mass Index and Other Risk Factors for Cancer in Adults with Cystic Fibrosis

Although cystic fibrosis patients are at higher risk of developing cancer, a Columbia gastroenterologist and cancer specialist discover that higher BMI was associated with reduced, not increased, risk of cancer in transplanted adults with cystic fibrosis.

image of geneticist performing cell analysis
Oncology, Women's Health

Validating the Effectiveness of Cascade Genetic Testing and Cancer Surveillance

Weill Cornell Medicine gynecologic oncology faculty conduct update prior research to further confirm that cascade testing can lead to genetically targeted primary disease prevention through screening and risk‐reducing surgery.

vector illustration of Immunostaining in human bladder tumor organoids
Oncology, Urology

Investigating Underlying Mechanisms in Bladder Cancer

A Columbia surgeon-scientist/urologic oncologist pursues translational research via patient-derived organoid lines to study the molecular profiles of non-muscle invasive and muscle invasive bladder tumors.

vector illustration of healthy and diseased livers
Gastroenterology, Oncology

Assessing Long-Term Cancer Risk in Alcohol-Related Liver Disease

An international research team that includes Columbia faculty in gastroenterology and hepatology evaluates the long-term risk of hepatocellular carcinoma in persons with ALD to determine if surveillance is warranted.

image of Scientist pipetting sample into a vial for DNA testing

Advancing the Early Detection of Pancreatic Cancer

At Columbia, Dr. Anil Rustgi presents insights into the current state of genetic testing, screening and surveillance with a goal to diagnose pancreatic cancer at a more treatable stage.

Images of uterine sarcoma and scalp lesion

Targeted Therapy Shows Promise for Aggressive Uterine Sarcoma

Columbia oncologists led a phase 2 clinical trial demonstrating the potential of olaparib combined with chemotherapy to treat patients with uterine leiomyosarcoma, a rare and deadly form of uterine cancer.

vector illustration of female body with red highlight over one breast

Reason for Optimism: Advancing Therapy for Triple-Negative Breast Cancer

Columbia breast oncologist co-chairs Expert Panel to develop ASCO Guideline Rapid Recommendation Update on adding immunotherapy to neoadjuvant chemotherapy to treat TNBC.

image of Non-solid nodule on CT screening for lung cancer

Tumor Microenvironment of Lung Cancer: What Lies Beneath?

Weill Cornell Medicine investigators examine the role of the tumor microenvironment in the progression of precancerous non-solid nodules that appear on CT to invasive lung adenocarcinoma.

CT Scan machine

A Paradigm Shift in Radiation Treatment Planning

Columbia radiation oncologists are using a new radiation delivery system that leverages artificial intelligence to create a personalized plan in minutes and offers better cancer control while further reducing radiation side effects.

medical concept 3D Illustration of Human Lymph Nodes System Anatomy

How Melanoma Prepares Lymph Nodes for Metastases

Weill Cornell Medicine cancer researchers uncover protein released in exosomes secreted by melanoma cells that leads to lymphangiogenesis.

Magnetic resonance contrast-enhanced axial T1 images

Promising Treatment Emerges for Recurrent Glioblastoma

Columbia neuro-oncologist leads international phase 2 trial of selinexor, the first of a new class of anticancer drugs.

image of Dr. Nasser Altorki and Dr. Silvia Formenti

Lung Cancer: Testing a Novel Protocol

Combining immune checkpoint blockade and radiotherapy preoperatively is associated with a significant enhancement of major pathological response in the treatment of early-stage non-small-cell lung cancer.

image of Diffuse large B-cell lymphoma

New Understanding of B-Cell Cancers

Weill Cornell Medicine and Columbia University faculty at NewYork-Presbyterian Hospital have uncovered new information on the roles of the microenvironment and genomic architecture underlying the development and progression of B-cell and other malignancies.

image of DNA strand and cancer cell oncology research concept 3D rendering

Novel Approaches to Personalizing Cancer Therapy

Scientists at Columbia University and Weill Cornell Medicine are applying contemporary methods of data analysis to generate algorithms that narrow the number of genetic drivers involved in cancer development.

image of a microscopic section immunostain

Accelerating Therapies for Challenging Blood Disorders

From studies in the laboratory to evaluating therapeutics in clinical trials, faculty at the NCI-designated Herbert Irving Comprehensive Cancer Center at Columbia University and the Weill Cornell Medicine Meyer Cancer Center in partnership with NewYork-Presbyterian are addressing the treatment challenges of blood disorders.

x-ray images of prostate cancer

Prolonging Life for Men with Prostate Cancer

Extending survival was the focus of a recent multinational phase 3 clinical trial of a combination therapy for men with nonmetastatic, castration-resistant prostate cancer. Led by Weill Cornell Medicine Oncology, the study provides evidence that adding androgen-receptor inhibitors to current therapies delays metastasis and improves survival.

digital medical illustration of lung cancer in the lungs

Non-Small Cell Lung Cancer: A New Combination for Neoadjuvant Therapy

A novel trial of chemotherapy combined with a PD-L1 inhibitor administered preoperatively in patients with resectable non-small cell lung cancer has had impressive results, raising expectations among oncologists and surgeons that they may soon have a new therapeutic strategy to offer patients with this life-threatening disease.

vector image of lymphomagenesis

Novel Research Advancing Cancer Care and Treatment

Studies by Columbia University and Weill Cornell Medicine faculty are making headlines in oncology research, providing promising evidence for new therapies and better understanding of the origins of blood and solid tumor cancers.

photomicrograph of a diffuse large B-cell lymphoma (DLBCL)

Extending the Boundaries of Cancer Care

NewYork-Presbyterian/Weill Cornell Medical Center is taking cancer care to the next level. Our healthcare providers are available to treat patients with advanced treatments like CAR T-cell therapy and provide access to clinical trials of promising new and innovative therapies.

image of Fibrosarcoma, light micrograph, photo under microscope

Exceptional Expertise in Rare Cancers

Combined rare cancers account for 50% of all cancer diagnoses. Researchers at the Herbert Irving Comprehensive Cancer Center at NewYork-Presbyterian/Columbia University Irving Medical Center are leading initiatives in rare cancers for cooperative study groups.

image of cancer cell

Investigating Immunotherapy Approaches in Genitourinary Oncology

Dr. Charles G. Drake initiated a cutting-edge trial in which androgen deprivation therapy is combined with a drug aimed at preventing suppressive myeloid cells from entering the prostate tumor microenvironment at the time of therapy.

image of Dr. Markus Y. Mapara

A New Take on BMT and Cellular Therapies

As the Adult Blood and Marrow Transplant Program at NewYork-Presbyterian/Columbia continues to expand, clinicians are investigating new treatment approaches ranging from autologous to allogeneic and haplo-identical transplantation.

image of Vitamin C, DHA conversion, and transport in KRAS and BRAF mutated cells

Confronting Solid Tumors: Vitamin C Takes on the KRAS Gene

With a multimillion dollar grant, investigators at NewYork-Presbyterian/Weill Cornell are conducting human trials to confirm that high doses of vitamin C impairs the growth of colorectal tumors.

image of Dr. Eleni Andreopoulou

Neoadjuvant Therapy in Breast Cancer: A New Raison D’être

In the past 50 years, use of neoadjuvant chemotherapy for breast cancer has evolved. Today, clinicians at NewYork-Presbyterian are using neoadjuvant therapy to tackle residual tumor.

image of cryotherapy to freeze a tumor

Targeting Early Breast Cancers with Ablation Therapies

Surgeons at NewYork-Presbyterian/Columbia are turning up the heat (or cold as the case may be) on early-stage breast cancer tumors with the use of ablation therapies.

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