How Is Blood Cancer Diagnosed?


A blood cancer diagnosis can be determined in several different ways. Depending on your type of blood cancer, your signs and symptoms, and personal and family history. Diagnosis may include:


Staging refers to determining the cancer's severity and level of metastasis, or spread. This helps predict how cancer will progress, allowing doctors to create a personalized blood cancer treatment plan. Diagnosing and staging may co-occur depending on the case, and the following tests and procedures may be used for both processes.

Physical exam

Your doctor will likely order a physical examination before anything else, feeling or looking for swollen lymph nodes and swelling in the liver or spleen. They may also examine the skin, checking for signs of easy bruising or bleeding and any rashes. To assess the nervous system, the doctor may check your balance, sensation, and reflexes.

Blood tests

Your doctor may perform a blood test for cancer detection and diagnosis. One or more of the following tests may be used:

Complete blood count (CBC)

A complete blood count may be ordered to determine levels of white blood cells, red blood cells, and platelets. Abnormal levels of these cells may indicate cancer.

White cell differential

A white cell differential, also referred to as a diff, determines the percentage of each type of white blood cell present in your blood. A differential can detect immature white blood cells and other abnormalities, indicating blood cancer.

Peripheral blood smear

A single drop of blood is smeared across a surface for analysis under a microscope during a peripheral blood smear. Cancer may be present if the appearance or levels of the blood cells in the sample are abnormal.

Imaging tests

Aside from blood tests, a range of imaging tests may also be used to diagnose blood cancer:

Computed tomography (CT) scan

CT scans combine several different X-ray images taken from various angles to provide cross-sectional views of the body's structures. This allows doctors to see parts various of the body in great detail. This test cannot be used to diagnose blood cancer, but if the organs or lymph nodes appear swollen in a CT scan, it may indicate that cancer is present.

Positron emission tomography (PET) scan

Typically more sensitive than other imaging tests, PET scans use a small amount of radioactive material inside the body to highlight areas where cancer cells are present. PET images may also be combined with CT scans to provide a more detailed view.

Magnetic resonance imaging (MRI) scan

MRIs use large magnets, radiofrequency, and a computer to create detailed images of the body's organs and structures, helping doctors determine whether cancer is present.


Ultrasounds release high-frequency sound waves into the body, which bounce off organs and bodily structures, creating "echoes." These echoes can then be turned into images, allowing doctors to analyze whether cancer is present in some body regions, such as the spleen or liver.


Your doctor may do a bone marrow or lymph node biopsy, in which a small piece of bone marrow or lymph node — or, in some cases, a whole lymph node — is removed to determine if cancer is present.

Bone marrow aspiration and biopsy

During the bone marrow aspiration, a needle is used to collect a small sample of liquid bone marrow (usually near the hip bone). Following this, a bone marrow biopsy is done to collect a solid portion of the bone marrow. Doctors can then analyze these samples to see if cancer may be affecting the blood, bone marrow, or blood-forming tissue. Local anesthesia helps to keep pain and pressure to a minimum during these diagnostic procedures.

Lymph node biopsy

During a lymph node biopsy, doctors will collect a partial or full sample of a lymph node. These biopsies can be done to diagnose a blood cancer, determine if the cancer has returned after treatment, or see if the blood cancer has become more aggressive. Depending on the location of the lymph node(s) needing biopsy, general or local anesthesia may be used.

Flow cytometry

Flow cytometry tests project lasers into bodily fluid streams containing cells or particles. These tests typically detect cancer cells in the bone marrow or blood when diagnosing blood cancers. The presence of certain protein markers, called antigens, can indicate cancer.


A urinalysis, a urine test, may also be used during a blood cancer diagnosis. This test measures the levels of proteins, chemicals, red blood cells, and white blood cells in the urine. If abnormal proteins are present, doctors may order further tests or procedures to determine if cancer or a disorder is present.

Lumbar puncture

A lumbar puncture, also referred to as a spinal tap, may be done to determine how advanced blood cancer has become. A needle is inserted into the lower back to collect cerebrospinal fluid (CSF), which surrounds the brain and spinal cord. Doctors can then analyze this sample to determine if cancer cells are present. Local anesthesia is used to numb the area before this procedure.

How is Blood Cancer Treated?

How is Blood Cancer Treated?

NewYork-Presbyterian offers complete care for all blood cancers — customizing your therapy to the type, stage, and biology of your disease, your age, and overall health.

Our expert medical team takes a holistic approach to blood cancers, focusing not just on the primary affected area, but on the entire body to ensure the best possible outcomes for our patients. We’ll work with you to help manage discomfort and treat any side effects that may come with blood cancer treatment.


Chemotherapy is the most common treatment for blood cancers. You may receive one drug or a combination of therapies. While some of these medications are taken by mouth, others are given intravenously.

Targeted therapies

Targeted anticancer drugs zero in on the molecular signals driving cancer growth. These treatments aim directly at cancer cells while sparing healthy cells, often resulting in fewer side effects than conventional chemotherapy

Bone marrow transplantation & CAR T-cell therapy

Bone marrow transplantation has evolved into the standard of care for many patients with blood cancers and blood disorders. Our center is certified and highly experienced in providing chimeric antigen receptor (CAR) T-cell therapy, a type of immunotherapy.

Allogeneic transplantation

With this transplant, you will receive stem cells from a matched related or unrelated donor — someone with a similar "human leukocyte antigen (HLA)" type. NewYork-Presbyterian offers more allogeneic transplants for older adults than any other center in the tri-state area. Haploidentical transplants done at both Cornell and Columbia have allowed more patients who do not have HLA-identical matches to be transplanted

Haplo-cord transplantation

Many patients lack a suitably matched donor, but they can still successfully undergo transplantation using a haplo-cord transplant. Through this process, patients receive stem cells from a single umbilical cord blood unit combined with stem cells from an adult donor who is partially matched to the patient. NewYork-Presbyterian/Weill Cornell Medical Center is especially well-known for its experience with haplo-cord transplants and is one of the few centers in the world offering them.

Radiation therapy

Radiation therapy is less commonly used to treat blood cancers, but it is sometimes used to treat blood cancer symptoms and to prepare for bone marrow transplantation. Radiation is also used to treat certain lymphomas. Our radiation therapy units feature the latest and most precise radiation therapy equipment.

Clinical trails

Clinical Trails

NewYork-Presbyterian and its academic medical school partners — Columbia University Vagelos College of Physicians and Surgeons and Weill Cornell Medicine — are home to a vigorous clinical and translational research program.

The successful treatment of many blood cancers relies on clinical trials. Your doctor will let you know if a clinical trial may be right for you. The decision to participate is entirely up to you.

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Trust NewYork-Presbyterian for Blood Cancer Treatment

NewYork-Presbyterian is proud to offer best-in-class treatment for all types of blood cancers and related disorders. Our dedicated team puts patients first, taking the time to understand your symptoms and concerns fully and create a comprehensive, customized treatment plan that will work for your specific needs.