Research is crucial to our mission. There are many unanswered questions in the field of ECMO that require careful scientific study. Your patients may be eligible for an ongoing research study. The patient's family would need to provide informed surrogate consent in order to participate in any of our studies.

NewYork-Presbyterian/Columbia has established itself as a world-leader in the delivery of modern ECMO therapy and developed innovative approaches to cannulation and patient management. Select publications include:

Ten-year outcomes of extracorporeal life support for in-hospital cardiac arrest at a tertiary center

Salna M, Sanchez J, Fried J, Masoumi A, Witer L, Kurlansky P, Agerstrand CL, Brodie D, Garan AR, Takeda K. Ten-year outcomes of extracorporeal life support for in-hospital cardiac arrest at a tertiary center. J Artif Organs. 2020 Dec;23(4):321-327. doi: 10.1007/s10047-020-01217-5. Epub 2020 Oct 3. PMID: 33009952.

The Role of Palliative Care in Withdrawal of Venoarterial Extracorporeal Membrane Oxygenation for Cardiogenic Shock

Godfrey S, Sahoo A, Sanchez J, Fried J, Masoumi A, Brodie D, Takayama H, Uriel N, Takeda K, Nakagawa S. The Role of Palliative Care in Withdrawal of Venoarterial Extracorporeal Membrane Oxygenation for Cardiogenic Shock. J Pain Symptom Manage. 2020 Nov 1:S0885-3924(20)30856-3. doi: 10.1016/j.jpainsymman.2020.10.027. Epub ahead of print. PMID: 33137423.

Extracorporeal membrane oxygenation support in COVID-19: an international cohort study of the Extracorporeal Life Support Organization registry

Barbaro RP, MacLaren G, Boonstra PS, Iwashyna TJ, Slutsky AS, Fan E, Bartlett RH, Tonna JE, Hyslop R, Fanning JJ, Rycus PT, Hyer SJ, Anders MM, Agerstrand CL, Hryniewicz K, Diaz R, Lorusso R, Combes A, Brodie D; Extracorporeal Life Support Organization. Extracorporeal membrane oxygenation support in COVID-19: an international cohort study of the Extracorporeal Life Support Organization registry. Lancet. 2020 Oct 10;396(10257):1071-1078. doi: 10.1016/S0140-6736(20)32008-0. Epub 2020 Sep 25. Erratum in: Lancet. 2020 Oct 10;396(10257):1070. PMID: 32987008; PMCID: PMC7518880.

Early venoarterial extracorporeal membrane oxygenation improves outcomes in post-cardiotomy shock

Saha A, Kurlansky P, Ning Y, Sanchez J, Fried J, Witer LJ, Kaku Y, Takayama H, Naka Y, Takeda K. Early venoarterial extracorporeal membrane oxygenation improves outcomes in post-cardiotomy shock. J Artif Organs. 2020 Sep 14. doi: 10.1007/s10047-020-01212-w. Epub ahead of print. PMID: 32926268.

Venoarterial extracorporeal membrane oxygenation to rescue sepsis-induced cardiogenic shock: a retrospective, multicentre, international cohort study

Bréchot N, Hajage D, Kimmoun A, Demiselle J, Agerstrand C, Montero S, Schmidt M, Luyt CE, Lebreton G, Hékimian G, Flecher E, Zogheib E, Levy B, Slutsky AS, Brodie D, Asfar P, Combes A; International ECMO Network. Venoarterial extracorporeal membrane oxygenation to rescue sepsis-induced cardiogenic shock: a retrospective, multicentre, international cohort study. Lancet. 2020 Aug 22;396(10250):545-552. doi: 10.1016/S0140-6736(20)30733-9. PMID: 32828186.

Temporary circulatory support for cardiogenic shock

Combes A, Price S, Slutsky AS, Brodie D. Temporary circulatory support for cardiogenic shock. Lancet. 2020 Jul 18;396(10245):199-212. doi: 10.1016/S0140-6736(20)31047-3. PMID: 32682486.

Approach to Acute Cardiovascular Complications in COVID-19 Infection

Ranard LS, Fried JA, Abdalla M, Anstey DE, Givens RC, Kumaraiah D, Kodali SK, Takeda K, Karmpaliotis D, Rabbani LE, Sayer G, Kirtane AJ, Leon MB, Schwartz A, Uriel N, Masoumi A. Approach to Acute Cardiovascular Complications in COVID-19 Infection. Circ Heart Fail. 2020 Jul;13(7):e007220. doi: 10.1161/CIRCHEARTFAILURE.120.007220. Epub 2020 Jun 5. PMID: 32500721.

The Variety of Cardiovascular Presentations of COVID-19

Fried JA, Ramasubbu K, Bhatt R, Topkara VK, Clerkin KJ, Horn E, Rabbani L, Brodie D, Jain SS, Kirtane AJ, Masoumi A, Takeda K, Kumaraiah D, Burkhoff D, Leon M, Schwartz A, Uriel N, Sayer G. The Variety of Cardiovascular Presentations of COVID-19. Circulation. 2020 Jun 9;141(23):1930-1936. doi: 10.1161/CIRCULATIONAHA.120.047164. Epub 2020 Apr 3. PMID: 32243205; PMCID: PMC7314498.

How I approach weaning from venoarterial ECMO

Fried JA, Masoumi A, Takeda K, Brodie D. How I approach weaning from venoarterial ECMO. Crit Care. 2020 Jun 8;24(1):307. doi: 10.1186/s13054-020-03010-5. PMID: 32513218; PMCID: PMC7278069.

Extracorporeal membrane oxygenation for primary graft dysfunction after heart transplant

DeRoo SC, Takayama H, Nemeth S, Garan AR, Kurlansky P, Restaino S, Colombo P, Farr M, Naka Y, Takeda K. Extracorporeal membrane oxygenation for primary graft dysfunction after heart transplant. J Thorac Cardiovasc Surg. 2019 Dec;158(6):1576-1584.e3. doi: 10.1016/j.jtcvs.2019.02.065. Epub 2019 Feb 28. PMID: 30948318.

Predictors of Survival for Patients with Acute Decompensated Heart Failure Requiring Extra-Corporeal Membrane Oxygenation Therapy

Garan AR, Malick WA, Habal M, Topkara VK, Fried J, Masoumi A, Hasan AK, Karmpaliotis D, Kirtane A, Yuzefpolskaya M, Farr M, Naka Y, Burkhoff D, Colombo PC, Kurlansky P, Takayama H, Takeda K. Predictors of Survival for Patients with Acute Decompensated Heart Failure Requiring Extra-Corporeal Membrane Oxygenation Therapy. ASAIO J. 2019 Nov/Dec;65(8):781-787. doi: 10.1097/MAT.0000000000000898. PMID: 30312208; PMCID: PMC6456436.

Midterm Outcomes of Bridge-to-Recovery Patients After Short-Term Mechanical Circulatory Support

Cheng YT, Garan AR, Sanchez J, Kurlansky P, Ando M, Cevasco M, Yuzefpolskaya M, Colombo PC, Naka Y, Takayama H, Takeda K. Midterm Outcomes of Bridge-to-Recovery Patients After Short-Term Mechanical Circulatory Support. Ann Thorac Surg. 2019 Aug;108(2):524-530. doi: 10.1016/j.athoracsur.2019.01.060. Epub 2019 Mar 6. PMID: 30851259.

Extracorporeal Life Support for Adults With Respiratory Failure and Related Indications: A Review

Brodie D, Slutsky AS, Combes A. Extracorporeal Life Support for Adults With Respiratory Failure and Related Indications: A Review. JAMA. 2019 Aug 13;322(6):557-568. doi: 10.1001/jama.2019.9302. PMID: 31408142.

Prospective Comparison of a Percutaneous Ventricular Assist Device and Venoarterial Extracorporeal Membrane Oxygenation for Patients With Cardiogenic Shock Following Acute Myocardial Infarction

Garan AR, Takeda K, Salna M, Vandenberge J, Doshi D, Karmpaliotis D, Kirtane AJ, Takayama H, Kurlansky P. Prospective Comparison of a Percutaneous Ventricular Assist Device and Venoarterial Extracorporeal Membrane Oxygenation for Patients With Cardiogenic Shock Following Acute Myocardial Infarction. J Am Heart Assoc. 2019 May 7;8(9):e012171. doi: 10.1161/JAHA.119.012171. PMID: 31041870; PMCID: PMC6512118.

Left ventricular distension and venting strategies for patients on venoarterial extracorporeal membrane oxygenation

Cevasco M, Takayama H, Ando M, Garan AR, Naka Y, Takeda K. Left ventricular distension and venting strategies for patients on venoarterial extracorporeal membrane oxygenation. J Thorac Dis. 2019 Apr;11(4):1676-1683. doi: 10.21037/jtd.2019.03.29. PMID: 31179113; PMCID: PMC6531683.

Left Ventricular Unloading During Extracorporeal Membrane Oxygenation in Patients With Cardiogenic Shock

Russo JJ, Aleksova N, Pitcher I, Couture E, Parlow S, Faraz M, Visintini S, Simard T, Di Santo P, Mathew R, So DY, Takeda K, Garan AR, Karmpaliotis D, Takayama H, Kirtane AJ, Hibbert B. Left Ventricular Unloading During Extracorporeal Membrane Oxygenation in Patients With Cardiogenic Shock. J Am Coll Cardiol. 2019 Feb 19;73(6):654-662. doi: 10.1016/j.jacc.2018.10.085. PMID: 30765031.

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome

Combes A, Hajage D, Capellier G, Demoule A, Lavoué S, Guervilly C, Da Silva D, Zafrani L, Tirot P, Veber B, Maury E, Levy B, Cohen Y, Richard C, Kalfon P, Bouadma L, Mehdaoui H, Beduneau G, Lebreton G, Brochard L, Ferguson ND, Fan E, Slutsky AS, Brodie D, Mercat A; EOLIA Trial Group, REVA, and ECMONet. Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome. N Engl J Med. 2018 May 24;378(21):1965-1975. doi: 10.1056/NEJMoa1800385. PMID: 29791822.

Preparing for the Most Critically Ill Patients With COVID-19: The Potential Role of Extracorporeal Membrane Oxygenation

MacLaren G, Fisher D, Brodie D. Preparing for the Most Critically Ill Patients With COVID-19: The Potential Role of Extracorporeal Membrane Oxygenation. JAMA. 2020 Apr 7;323(13):1245-1246. doi: 10.1001/jama.2020.2342. PMID: 32074258.

Extracorporeal Carbon Dioxide Removal in the Treatment of Status Asthmaticus

Bromberger BJ, Agerstrand C, Abrams D, Serra A, Apsel D, Tipograf Y, Ginsburg ME, Ebright MI, Stanifer BP, Oommen R, Bacchetta M, Brodie D, Sonett JR. Extracorporeal Carbon Dioxide Removal in the Treatment of Status Asthmaticus. Crit Care Med. 2020 Oct 7. doi: 10.1097/CCM.0000000000004645. Epub ahead of print. PMID: 33031151.

Extracorporeal life support bridge for pulmonary hypertension: A high-volume single-center experience

Rosenzweig EB, Gannon WD, Madahar P, Agerstrand C, Abrams D, Liou P, Brodie D, Bacchetta M. Extracorporeal life support bridge for pulmonary hypertension: A high-volume single-center experience. J Heart Lung Transplant. 2019 Dec;38(12):1275-1285. doi: 10.1016/j.healun.2019.09.004. Epub 2019 Sep 12. PMID: 31582284.

Outcomes of Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplantation

Tipograf Y, Salna M, Minko E, Grogan EL, Agerstrand C, Sonett J, Brodie D, Bacchetta M. Outcomes of Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplantation. Ann Thorac Surg. 2019 May;107(5):1456-1463. doi: 10.1016/j.athoracsur.2019.01.032. Epub 2019 Feb 18. PMID: 30790550.

A decade of interfacility extracorporeal membrane oxygenation transport

Tipograf Y, Liou P, Oommen R, Agerstrand C, Abrams D, Brodie D, Bacchetta M. A decade of interfacility extracorporeal membrane oxygenation transport. J Thorac Cardiovasc Surg. 2019 Apr;157(4):1696-1706. doi: 10.1016/j.jtcvs.2018.09.139. Epub 2018 Nov 29. PMID: 30655061.

Mechanical Ventilation for Acute Respiratory Distress Syndrome during Extracorporeal Life Support. Research and Practice

Abrams D, Schmidt M, Pham T, Beitler JR, Fan E, Goligher EC, McNamee JJ, Patroniti N, Wilcox ME, Combes A, Ferguson ND, McAuley DF, Pesenti A, Quintel M, Fraser J, Hodgson CL, Hough CL, Mercat A, Mueller T, Pellegrino V, Ranieri VM, Rowan K, Shekar K, Brochard L, Brodie D. Mechanical Ventilation for Acute Respiratory Distress Syndrome during Extracorporeal Life Support. Research and Practice. Am J Respir Crit Care Med. 2020 Mar 1;201(5):514-525. doi: 10.1164/rccm.201907-1283CI. PMID: 31726013.

ECMO for ARDS: from salvage to standard of care?

Abrams D, Ferguson ND, Brochard L, Fan E, Mercat A, Combes A, Pellegrino V, Schmidt M, Slutsky AS, Brodie D. ECMO for ARDS: from salvage to standard of care? Lancet Respir Med. 2019 Feb;7(2):108-110. doi: 10.1016/S2213-2600(18)30506-X. Epub 2019 Jan 11. Erratum in: Lancet Respir Med. 2019 Feb;7(2):e9. PMID: 30642778.

Adult ECMO Program NewYork-Presbyterian/Columbia

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