Heart Failure Research Institute

Advancing the understanding, prevention, and treatment of heart failure through research

Our Research

Our world-renowned experts, including physicians and scholars from Weill Cornell Medicine and Columbia University Vagelos College of Physicians and Surgeons, are on the leading edge of heart failure research. 

Discover our latest publications, areas of interest, and how we’re advancing the field.

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Recent Publications

Amyloidosis

Impact of Vutrisiran on Cardiac Biomarkers in Patients With Transthyretin Amyloidosis With Cardiomyopathy From HELIOS-B 

Maurer MS, Berk JL, Damy T, Sheikh FH, González-Costello J, Morbach C, Delgado D, Bondue A, Azevedo O, Poulsen SH, Jankowska EA, Yang L, Bender S, Eraly SA, Jay PY, Vest J, Fontana M. Impact of Vutrisiran on Cardiac Biomarkers in Patients With Transthyretin Amyloidosis With Cardiomyopathy From HELIOS-B. J Am Coll Cardiol. 2025 Aug 12;86(6):459-475. doi: 10.1016/j.jacc.2025.04.055. PMID: 40769675.


Acoramidis for Transthyretin Amyloid Cardiomyopathy: Open-Label Extension Study Long-Term Follow-Up

Masri A, Aras M, Grogan M, Jacoby D, Maurer MS, Shah SJ, Witteles R, Wong PW, Ji AX, DU J, Siddhanti S, Katz L, Sinha U, Fox JC, Judge DP. Acoramidis for Transthyretin Amyloid Cardiomyopathy: Open-Label Extension Study Long-Term Follow-Up. J Card Fail. 2025 Aug;31(8):1354-1359. doi: 10.1016/j.cardfail.2025.03.017. Epub 2025 Apr 9. PMID: 40216220.


Transthyretin Cardiac Amyloidosis in Older Black and Hispanic Individuals With Heart Failure

Ruberg FL, Teruya S, Helmke S, Smiley DA, Fine D, Kurian D, Raiszadeh F, Prokaeva T, Spencer B, Wong S, Pandey S, Blaner WS, DeLuca A, Johnson LL, Kinkhabwala MP, Leb J, Mintz A, LaValley MP, Einstein AJ, Cohn E, Gallegos C, Murtagh G, Kelly JW, Miller EJ, Maurer MS. Transthyretin Cardiac Amyloidosis in Older Black and Hispanic Individuals With Heart Failure. JAMA Cardiol. 2025 Oct 1;10(10):1034-1043. doi: 10.1001/jamacardio.2025.2948. PMID: 40928765; PMCID: PMC12423950.


Prognostic Value of Malnutrition, Frailty, and Physical Performance in Transthyretin Cardiac Amyloidosis: Insights From a Prospective Multicenter Cohort Study

Fumagalli C, Zampieri M, Presta R, Pini G, Vetere G, Argirò A, Longhi S, Tini G, Musumeci B, Limongelli G, Palmiero G, Verrillo F, Beltrami M, Bo M, De Ferrari G, Tofani L, Sardu C, Marfella R, Marchionni N, Perfetto F, Olivotto I, Fumagalli S, Maurer MS, Fontana M, Ungar A, Cappelli F. Prognostic Value of Malnutrition, Frailty, and Physical Performance in Transthyretin Cardiac Amyloidosis: Insights From a Prospective Multicenter Cohort Study. Circ Heart Fail. 2025 Sep;18(9):e012777. doi: 10.1161/CIRCHEARTFAILURE.125.012777. Epub 2025 Jul 2. PMID: 40600269; PMCID: PMC12435243.


Statin use in transthyretin amyloid cardiomyopathy: Assessing tolerability and drug interaction risks with tafamidis

Talasaz AH, Cuomo MO, Maurer MS. Statin use in transthyretin amyloid cardiomyopathy: Assessing tolerability and drug interaction risks with tafamidis. J Clin Lipidol. 2025 Aug 21:S1933-2874(25)00378-2. doi: 10.1016/j.jacl.2025.08.015. Epub ahead of print. PMID: 40973549.


Early Access to Tafamidis for Patients With Transthyretin Amyloid Cardiomyopathy

Crespo-Leiro MG, Hanna M, Damy T, Delgado D, Ebede B, Marino V, Wang R, Maurer MS, Garcia-Pavia P, Drachman BM. Early Access to Tafamidis for Patients With Transthyretin Amyloid Cardiomyopathy. JACC Adv. 2025 Oct;4(10 Pt 2):102122. doi: 10.1016/j.jacadv.2025.102122. Epub 2025 Sep 10. PMID: 40934814.


Prevalence and Phenotype of Transthyretin Val122Ile Variant in the Hispanic Community Health Study/Study of Latinos

Duran-Luciano P, Pandey A, Swett K, Talavera GA, Daviglus M, Hurwitz BE, Shah SJ, Sofer T, Solomon SD, Cheng S, Aviles-Santa L, Parada H Jr, Thyagarajan B, Gonzalez F 2nd, Kansal MM, Tauras J, Maurer MS, Rodriguez CJ. Prevalence and Phenotype of Transthyretin Val122Ile Variant in the Hispanic Community Health Study/Study of Latinos. JACC Adv. 2025 Aug;4(8):102034. doi: 10.1016/j.jacadv.2025.102034. Epub 2025 Jul 25. PMID: 40714577; PMCID: PMC12318275.


Long-term follow-up of patients with AL amyloidosis treated on a phase 1 trial of CAEL-101

Hughes MS, Pan S, Chakraborty R, Raikhelkar J, Maurer MS, Mapara MY, Eisenberger A, Lentzsch S, Bhutani D. Long-term follow-up of patients with AL amyloidosis treated on a phase 1 trial of CAEL-101. Blood Adv. 2025 Oct 14;9(19):4946-4950. doi: 10.1182/bloodadvances.2025016731. PMID: 40674707; PMCID: PMC12513277.


Risk for Heart Failure and Atrial Fibrillation Across the Lifespan for Carriers of the Amyloidogenic p.V142I TTR Variant

Grodin JL, Gupta A, Rison I Jr, Kozlitina J, Saelices-Gomez L, Girotra S, Shah AM, Roth LR, Griffin JM, Drazner MH, Tang WHW, Maurer MS, de Lemos JA. Risk for Heart Failure and Atrial Fibrillation Across the Lifespan for Carriers of the Amyloidogenic p.V142I TTR Variant. Circ Genom Precis Med. 2025 Aug;18(4):e004911. doi: 10.1161/CIRCGEN.124.004911. Epub 2025 Jul 23. PMID: 40698407; PMCID: PMC12313181.


Previous total knee or total hip arthroplasty and association with amyloidosis - a Danish nationwide study

Noory N, Havers-Borgersen E, Westin O, Maurer MS, Køber L, Gustafsson F, Fosbøl E. Previous total knee or total hip arthroplasty and association with amyloidosis - a Danish nationwide study. Amyloid. 2025 Sep;32(3):283-285. doi: 10.1080/13506129.2025.2495168. Epub 2025 Apr 24. PMID: 40272383.


Clinical Implications of the P.V142I TTR Variant: Insights From CARS 

Wees IR, Ayers C, Ruberg FL, Maurer MS, Brailovsky Y, Stern LK, Griffin JM, Khouri MG, Roth LR, Grodin JL. Clinical Implications of the P.V142I TTR Variant: Insights From CARS. JACC Heart Fail. 2025 Oct 9:102704. doi: 10.1016/j.jchf.2025.102704. Epub ahead of print. PMID: 41074899.


Effect of Acoramidis on Recurrent and Cumulative Cardiovascular Outcomes in ATTR-CM: Exploratory Analysis From ATTRibute-CM

Masri A, Judge DP, Ruberg FL, Gillmore JD, Grodin JL, Obici L, Maurer MS, Fontana M, Poulsen SH, van der Meer P, Cheng RK, Cuddy SAM, Ambardekar AV, Xiong K, Cao X, Murtagh G, Siddhanti S, Castaño A, Tamby JF, Fox JC, Alexander KM, Witteles R. Effect of Acoramidis on Recurrent and Cumulative Cardiovascular Outcomes in ATTR-CM: Exploratory Analysis From ATTRibute-CM. J Am Coll Cardiol. 2025 Sep 28:S0735-1097(25)07774-5. doi: 10.1016/j.jacc.2025.09.013. Epub ahead of print. PMID: 41143759.


A cautionary case series: tafamidis mistreatment following erroneous diagnosis of transthyretin cardiac amyloidosis

Muchtar E, Gonzalez Bonilla H, Sanchorawala V, Gurijala N, Masri A, Davis B, Abou Ezzeddine O, Milani P, Palladini G, Cuomo M, Maurer M, Grogan M. A cautionary case series: tafamidis mistreatment following erroneous diagnosis of transthyretin cardiac amyloidosis. Amyloid. 2025 Sep 11:1-4. doi: 10.1080/13506129.2025.2553525. Epub ahead of print. PMID: 40932302.

Artificial intelligence

Detecting structural heart disease from electrocardiograms using AI

Poterucha TJ, Jing L, Ricart RP, Adjei-Mosi M, Finer J, Hartzel D, Kelsey C, Long A, Rocha D, Ruhl JA, vanMaanen D, Probst MA, Daniels B, Joshi SD, Tastet O, Corbin D, Avram R, Barrios JP, Tison GH, Chiu IM, Ouyang D, Volodarskiy A, Castillo M, Roedan Oliver FA, Malta PP, Ye S, Rosner GF, Dizon JM, Ali SR, Liu Q, Bradley CK, Vaishnava P, Waksmonski CA, DeFilippis EM, Agarwal V, Lebehn M, Kampaktsis PN, Shames S, Beecy AN, Kumaraiah D, Homma S, Schwartz A, Hahn RT, Leon M, Einstein AJ, Maurer MS, Hartman HS, Hughes JW, Haggerty CM, Elias P. Detecting structural heart disease from electrocardiograms using AI. Nature. 2025 Aug;644(8075):221-230. doi: 10.1038/s41586-025-09227-0. Epub 2025 Jul 16. PMID: 40670798; PMCID: PMC12328201.

Heart failure & pulmonary hypertension

Seralutinib for the Treatment of Pulmonary Arterial Hypertension in Adults: TORREY Open-Label Extension Study

Sitbon O, Sahay S, Escribano Subías P, Zolty RL, Kingrey JF, Ryan JJ, Sobol I, Sood N, Benza RL, Channick RN, Chin KM, Frantz RP, Ghofrani HA, Hemnes AR, McLaughlin VV, Vachiéry JL, Zamanian RT, Ter Veer A, Roscigno RF, Mottola D, Parsley E, Aranda R, Zisman LS, Howard LS; TORREY Study Investigators. Seralutinib for the Treatment of Pulmonary Arterial Hypertension in Adults: TORREY Open-Label Extension Study. Adv Ther. 2025 Oct;42(10):5104-5123. doi: 10.1007/s12325-025-03297-2. Epub 2025 Aug 11. PMID: 40788460; PMCID: PMC12474731.


Metabolomic Evidence of Biological Overlap with Heart Failure with Preserved Ejection Fraction in a Subset of Pulmonary Arterial Hypertension 

Reddy YNV, Asokan AK, Frantz RP, Hemnes A, Hassoun PM, Barnard J, Horn E, Leopold JA, Rischard F, Rosenzweig EB, Hill NS, Erzurum SC, Beck GJ, Finet JE, Grunig G, Jellis CL, Mathai SC, Simpson CE, Tang WHW, Nair KS, Borlaug BA. Metabolomic Evidence of Biological Overlap with Heart Failure with Preserved Ejection Fraction in a Subset of Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2025 Sep;211(9):1701-1713. doi: 10.1164/rccm.202501-0034OC. PMID: 40504754; PMCID: PMC12432440.


Echocardiographic Parameters and Risk Prediction in Pulmonary Arterial Hypertension: Insights From the Redefining Pulmonary Hypertension Through Pulmonary Vascular Disease Phenomics Network

Mukherjee M, Jani VP, Osgueritchian R, Mombeini H, Abidov A, Beck G, Erzurum S, Frantz RP, Hassoun PM, Hemnes AR, Hill NS, Horn EM, Kim J, Kwon D, Larive AB, Leary PJ, Leopold JA, Mathai SC, Mehra R, Park MM, Rosenzweig EB, Tang WHW, Jellis CL, Rischard FP, Badagliacca R; Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics Network. Echocardiographic Parameters and Risk Prediction in Pulmonary Arterial Hypertension: Insights From the Redefining Pulmonary Hypertension Through Pulmonary Vascular Disease Phenomics Network. Chest. 2025 Aug;168(2):502-519. doi: 10.1016/j.chest.2025.04.007. Epub 2025 Apr 12. PMID: 40222714; PMCID: PMC12405913.

 

Left Heart Abnormalities in Patients With Lung Disease, OSA, and Chronic Thromboemboli at Risk for or With Known Pulmonary Hypertension

Reddy YNV, Frantz RP, Hassoun PM, Hemnes A, Horn E, Leopold JA, Rischard F, Rosenzweig EB, Hill NS, Erzurum SC, Beck GJ, Finet JE, Jellis CL, Mathai SC, Mehra R, Tang WHW, Borlaug BA; PVDOMICS Study Group. Left Heart Abnormalities in Patients With Lung Disease, OSA, and Chronic Thromboemboli at Risk for or With Known Pulmonary Hypertension. Circ Heart Fail. 2025 Aug;18(8):e012912. doi: 10.1161/CIRCHEARTFAILURE.125.012912. Epub 2025 May 29. PMID: 40438933; PMCID: PMC12353934.

 

Right ventricular global work efficiency: A reliable non-invasive estimate of right ventricular contractility

Manca P, Nuzzi V, Lucchino A, Rugiano G, Mulè M, Carvelli A, Cannata S, Sciacca S, Parisi F, Sorrentino S, Faletra FF, Colombo PC, Cipriani MG. Right ventricular global work efficiency: A reliable non-invasive estimate of right ventricular contractility. ESC Heart Fail. 2025 Oct;12(5):3719-3730. doi: 10.1002/ehf2.15354. Epub 2025 Jul 3. PMID: 40607591; PMCID: PMC12450761.

 

Echo-Doppler Predictors of Residual Pulmonary Hypertension After Pulmonary Thromboendarterectomy

Oliveros E, Jonnalagadda A, Pietrowicz R, Mauri M, Zhao H, Maruthi R, Saunders H, Lakhter V, Brailovsky Y, Bashir R, Sadek A, Vaidya A, Forfia P. Echo-Doppler Predictors of Residual Pulmonary Hypertension After Pulmonary Thromboendarterectomy. J Clin Med. 2025 Aug 12;14(16):5705. doi: 10.3390/jcm14165705. PMID: 40869530; PMCID: PMC12386797.

 

Attenuated benefit to vasodilators in patients with pulmonary arterial hypertension and high probability of heart failure with preserved ejection fraction

Reddy YNV, Frantz RP, Dubrock HM, Hemnes AR, Horn EM, De Marco T, Burger C, Mathai SC, Kawut SM, Borlaug BA; PHAR investigators. Attenuated benefit to vasodilators in patients with pulmonary arterial hypertension and high probability of heart failure with preserved ejection fraction. Eur Respir J. 2025 Sep 17;66(3):2500880. doi: 10.1183/13993003.00880-2025. PMID: 40639872.

 

Nonischemic Septal Fibrosis in Functional Tricuspid Regurgitation Provides Incremental Stratification of Adverse Remodeling and Prognosis

Villar-Calle P, Pai V, Zhang RS, Reza M, Jin L, Axman R, Falk Z, Falco G, RoyChoudhury A, Chen S, Mosadegh B, Kodali SK, Khalique OK, Horn EM, Weinsaft JW, Kim J. Nonischemic Septal Fibrosis in Functional Tricuspid Regurgitation Provides Incremental Stratification of Adverse Remodeling and Prognosis. JACC Cardiovasc Imaging. 2025 Sep;18(9):959-969. doi: 10.1016/j.jcmg.2025.03.015. Epub 2025 Jul 3. PMID: 40608040; PMCID: PMC12362310.

 

Loneliness and Risk of 30-Day Hospital Readmission After Acute Myocardial Infarction

Acker C, Soroka O, Sterling MR, Goyal P, Safford MM, Pinheiro LC. Loneliness and Risk of 30-Day Hospital Readmission After Acute Myocardial Infarction. Med Care. 2025 Sep 15. doi: 10.1097/MLR.0000000000002217. Epub ahead of print. PMID: 40971549.

 

Pulmonary Artery Size on CT Associates with Mean Pulmonary Artery Pressure and Mortality

Couch TJ, Beck GJ, Rozenzweig EB, Carr JJ, Erzurum SC, Frantz RP, Hassoun PM, Hill NS, Horn EM, Lempel JK, Leopold JA, Nian H, Ray DN, Rischard FP, Schwalbach KT, Terry JG, Hemnes AR. Pulmonary Artery Size on CT Associates with Mean Pulmonary Artery Pressure and Mortality. Ann Am Thorac Soc. 2025 Oct 15. doi: 10.1513/AnnalsATS.202507-831OC. Epub ahead of print. PMID: 41092241.

 

Atrial Fibrillation Worsens Right Ventricular Dysfunction and Outcomes in Acute Pulmonary Embolism

Mallery Q, Choi MH, Koura S, Greathouse F, Clarke J, Gadhoke N, Sharma A, Elkaryoni A, Desai P, Brailovsky Y, Darki A. Atrial Fibrillation Worsens Right Ventricular Dysfunction and Outcomes in Acute Pulmonary Embolism. Am J Cardiol. 2025 Oct 6;257:153-158. doi: 10.1016/j.amjcard.2025.09.045. Epub ahead of print. PMID: 41045956.

 

Appropriateness of Antiplatelets and Anticoagulants Among Older Adults Experiencing Falls

Klickstein LC, Niznik J, Branham V, George H, Meyer ML, Busby-Whitehead J, Davenport K, Roberts E, Goyal P, Goldberg E, Casey MF. Appropriateness of Antiplatelets and Anticoagulants Among Older Adults Experiencing Falls. J Am Geriatr Soc. 2025 Sep 27. doi: 10.1111/jgs.70127. Epub ahead of print. PMID: 41014071.

 

Representation of Older Adults in the AHA/ACC/HFSA Guideline for the Management of Heart Failure

Jamil Y, El Ghazawi A, Farhat K, Nouri A, Goyal P, Damluji AA, Nanna MG, Samsky MD. Representation of Older Adults in the AHA/ACC/HFSA Guideline for the Management of Heart Failure. JACC Adv. 2025 Oct 4:102135. doi: 10.1016/j.jacadv.2025.102135. Epub ahead of print. PMID: 41128709.

 

Incident Heart Failure in Adults With Mild to Moderate Chronic Kidney Disease

Girouard MP, Go AS, Liu JY, Parikh RV, Tan TC, Lee ES, Sun G, Halaseh R, Bhatt AS, Pravoverov L, Zheng S, Svetlichnaya J, Fitzpatrick JK, Avula HR, Lee KK, Adatya S, Ouyang D, Goyal P, Sandhu AT, Ambrosy AP. Incident Heart Failure in Adults With Mild to Moderate Chronic Kidney Disease. JACC Heart Fail. 2025 Aug 18:102616. doi: 10.1016/j.jchf.2025.102616. Epub ahead of print. PMID: 40888788.

 

Derivation of a Personalized Congestion Score Using a Chronic Implantable Inferior Vena Cava Management System in Heart Failure: An Analysis from the FUTURE-HF Trial Portfolio

Fudim M, Mehra MR, Damman K, Uriel N, Kalra PR, Sweeney F, Carmody D, Tucker J, Greene BR, Testani JM; Future HF Portfolio Investigators. Derivation of a Personalized Congestion Score Using a Chronic Implantable Inferior Vena Cava Management System in Heart Failure: An Analysis from the FUTURE-HF Trial Portfolio. J Card Fail. 2025 Sep 28:S1071-9164(25)00430-0. doi: 10.1016/j.cardfail.2025.09.018. Epub ahead of print. PMID: 41027509.

 

Dietary Inflammatory Score and Incident Heart Failure in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study

Park CM, Balkan L, Ringel JB, Shikany J, Bostick R, Judd SE, Jonas C, Arora P, Brown TM, Durant R, Hummel S, Jackson EA, Sterling MR, Demmer R, Yuzefpolskaya M, Levitan EB, Safford MM, Goyal P. Dietary Inflammatory Score and Incident Heart Failure in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study. J Card Fail. 2025 Sep;31(9):1440-1449. doi: 10.1016/j.cardfail.2024.12.009. Epub 2025 Jan 14. PMID: 39818266; PMCID: PMC12256639.

 

Social Drivers of Health in Heart Failure Trials: An Analysis From the Heart Failure Collaboratory

DeFilippis EM, Blumer V, Makuvire TT, Echols MR, Adamson PB, Solomon S, Pina IL, Stein KM, Vaduganathan M, Walsh MN, Vardeny O, Jessup M, Yancy CW, Lindenfeld J, O'Connor CM, Fiuzat M. Social Drivers of Health in Heart Failure Trials: An Analysis From the Heart Failure Collaboratory. JACC Heart Fail. 2025 Sep;13(9):102546. doi: 10.1016/j.jchf.2025.102546. Epub 2025 Jul 17. PMID: 40680703.

 

Endothelial Cell-Related Proteins in Plasma Predict Major Adverse Cardiovascular Events and Worsening Heart Failure in Patients With Hypertrophic Cardiomyopathy

Tamura S, Akita K, Fifer MA, Tower-Rader A, Maurer MS, Shimada YJ. Endothelial Cell-Related Proteins in Plasma Predict Major Adverse Cardiovascular Events and Worsening Heart Failure in Patients With Hypertrophic Cardiomyopathy. J Am Heart Assoc. 2025 Oct 21;14(20):e042887. doi: 10.1161/JAHA.125.042887. Epub 2025 Oct 9. PMID: 41065251.

Heart transplantation


Efficacy and safety of belatacept in heart transplant recipients

Baranowska J, Oren D, Valledor AF, Uriel M, Lee C, Moeller CM, Elad B, Rahman S, Hertz A, Skoll D, Regan M, DeFilippis EM, Raikhelkar J, Fried J, Lotan D, Oh KT, Bae D, Rahman A, Choe J, Clerkin K, Yunis AA, Yuzefpolskaya M, Colombo PC, Majure D, Latif F, Sayer G, Uriel N. Efficacy and safety of belatacept in heart transplant recipients. J Heart Lung Transplant. 2025 Oct;44(10):1612-1620. doi: 10.1016/j.healun.2025.04.023. Epub 2025 May 28. PMID: 40446881.


Sarcopenia Assessment Using Fully Automated Deep Learning Predicts Cardiac Allograft Survival in Heart Transplant Recipients 

Lang FM, Liu J, Clerkin KJ, Driggin EA, Einstein AJ, Sayer GT, Takeda K, Uriel N, Summers RM, Topkara VK. Sarcopenia Assessment Using Fully Automated Deep Learning Predicts Cardiac Allograft Survival in Heart Transplant Recipients. Circ Heart Fail. 2025 Oct;18(10):e012805. doi: 10.1161/CIRCHEARTFAILURE.125.012805. Epub 2025 Aug 20. PMID: 40832698.


Extracorporeal Photopheresis in the Treatment of Cardiac Allograft Rejection in the Modern Era: A Single-Center Experience

Rubinstein G, Valledor AF, Moeller CM, Baranowska J, Oren D, Oh DKT, Bae D, Yunis A, Lotan D, Rahman A, Raikhelkar JK, Fried JA, DeFilippis EM, Clerkin KJ, Latif F, Sayer GT, Uriel N. Extracorporeal Photopheresis in the Treatment of Cardiac Allograft Rejection in the Modern Era: A Single-Center Experience. Clin Transplant. 2025 Aug;39(8):e70247. doi: 10.1111/ctr.70247. PMID: 40698560.


Screening and Surveillance for Colorectal Cancer Before and After Heart Transplantation 

Abrams ME, Keller E, Lemos C, Regan M, O'Connell DC, Salgado SM, Donald E, Salazar R, Hennecken C, Raikhelkar JK, Latif F, Clerkin KJ, Sayer G, Uriel N, DeFilippis EM. Screening and Surveillance for Colorectal Cancer Before and After Heart Transplantation. Clin Transplant. 2025 Sep;39(9):e70301. doi: 10.1111/ctr.70301. PMID: 40965853.


Correlation between donor-derived cell-free DNA and tissue gene expression in heart transplant patients undergoing for-cause endomyocardial biopsies

Valledor AF, Moeller CM, Oren D, Baranowska J, Rahman S, Hertz A, Rahman A, Hennecken C, Rubinstein G, Elad B, Richter I, Lotan D, Regan M, LaBarre B, Yunis A, Fried J, DeFilippis EM, Colombo PC, Yuzefpolskaya M, Raihkelkar J, Latif F, Clerkin KD, Majure DT, Sayer GT, Uriel N. Correlation between donor-derived cell-free DNA and tissue gene expression in heart transplant patients undergoing for-cause endomyocardial biopsies. J Heart Lung Transplant. 2025 Sep;44(9):1384-1393. doi: 10.1016/j.healun.2025.04.019. Epub 2025 May 13. PMID: 40374050.


Outcomes After Heart Transplantation Among Non-Native English-Speaking Recipients

Vargas F, Batra J, Lemos C, Magun E, Salazar RA, Taylor CN, Donald EM, Driggin E, Regan M, McArthur-Murphy R, Lumish H, Concha D, Chung A, Golob S, Latif F, Clerkin KJ, Takeda K, Sayer G, Uriel N, Defilippis EM. Outcomes After Heart Transplantation Among Non-Native English-Speaking Recipients. J Card Fail. 2025 Oct;31(10):1534-1543. doi: 10.1016/j.cardfail.2024.12.010. Epub 2025 Jan 20. PMID: 39842708.


Clinical Utility of Combined Donor-Derived Cell-Free DNA and Peripheral Gene-Expression-Profiling in Heart Transplant Recipients 

Moeller CM, Valledor AF, Oren D, Rahman S, Rahman A, Regan M, Lee C, Hertz A, Rubinstein G, Baranowska J, Elad B, Hennecken C, Salazar R, Oren A, Donald EM, Lotan D, Oh KT, Bae D, Yunis A, Majure D, Yuzefpolskaya M, Colombo PC, Raikhelkar JK, Fried JA, DeFilippis EM, Takeda K, Clerkin KJ, Latif F, Sayer GT, Uriel N. Clinical Utility of Combined Donor-Derived Cell-Free DNA and Peripheral Gene-Expression-Profiling in Heart Transplant Recipients. Clin Transplant. 2025 Oct;39(10):e70340. doi: 10.1111/ctr.70340. PMID: 41085484.


Impact of Donor and Recipient Sex-Mismatch in Donation After Circulatory Death Heart Transplant

Rajesh K, Feng I, Latif F, Sayer G, Uriel N, Kaku Y, Naka Y, Kurlansky P, Takeda K. Impact of Donor and Recipient Sex-Mismatch in Donation After Circulatory Death Heart Transplant. Clin Transplant. 2025 Sep;39(9):e70285. doi: 10.1111/ctr.70285. PMID: 40891331.


Significance of Elevated Donor-Derived Cell-Free DNA in Heart Transplant Recipients With Negative Endomyocardial Biopsies: A Dawn of a New Era

Moeller CM, Fernandez Valledor A, Oren D, Rahman S, Baranowska J, Hertz A, DeFilippis EM, Lee C, Regan M, Oren A, Rahman A, Hennecken C, Salazar R, Donald EM, Lotan D, Majure D, Yuzefpolskaya M, Colombo PC, Raikhelkar JK, Fried JA, Clerkin KJ, Latif F, Sayer GT, Uriel N. Significance of Elevated Donor-Derived Cell-Free DNA in Heart Transplant Recipients With Negative Endomyocardial Biopsies: A Dawn of a New Era. Circ Heart Fail. 2025 Sep 30:e012787. doi: 10.1161/CIRCHEARTFAILURE.125.012787. Epub ahead of print. PMID: 41025234.


Comparable short-term survival in dual organ heart transplant recipients with and without HIV: A call for increased access to organ donation for people living with HIV

Donald EM, Batra J, DeFilippis EM, Raikhelkar JK, Lotan D, Clerkin KJ, Sayer G, Uriel N. Comparable short-term survival in dual organ heart transplant recipients with and without HIV: A call for increased access to organ donation for people living with HIV. Am J Transplant. 2025 Sep;25(9):1996-2007. doi: 10.1016/j.ajt.2025.05.004. Epub 2025 May 7. PMID: 40345498.


Sex Differences in Utilization of Donation After Circulatory Death Donors for Heart Transplantation and Associated Outcomes

DeFilippis EM, Masotti M, Donald EM, Eichler J, Ramu B, Watt T, Mulvihill MS, Takeda K, Uriel N, Cogswell R. Sex Differences in Utilization of Donation After Circulatory Death Donors for Heart Transplantation and Associated Outcomes. Circ Heart Fail. 2025 Aug;18(8):e012835. doi: 10.1161/CIRCHEARTFAILURE.125.012835. Epub 2025 Jun 26. PMID: 40567220.


Posttransplant rituximab exposure and risk of PTLD in solid organ transplant recipients with EBV DNAemia

Orlando EH, Gould P, Cuzzo B, Ford M, Chen Y, Sanjurjo A, Jain S, May B, Tsapepas D, Leeman-Neill RJ, Bhagat G, Dube GK, Morris H, Arcasoy S, Latif F, DeFilippis EM, Martinez M, Im GY, Phipps MM, Pereira MR, Sue PK, Orjuela-Grimm M, Lipsky AH, Sawas A, Reshef R, Pro B, Cherng HJ, Amengual JE. Posttransplant rituximab exposure and risk of PTLD in solid organ transplant recipients with EBV DNAemia. Blood Neoplasia. 2025 Aug 19;2(4):100160. doi: 10.1016/j.bneo.2025.100160. PMID: 41127866; PMCID: PMC12538014.


Surveillance Patterns for Allograft Vasculopathy in Heart Transplant Recipients in PET Myocardial Perfusion Imaging Performing Centers in the United States

Feher A, Alwan M, Wright CX, Clerkin KJ, Einstein AJ, Miller EJ, Al-Mallah MH. Surveillance Patterns for Allograft Vasculopathy in Heart Transplant Recipients in PET Myocardial Perfusion Imaging Performing Centers in the United States. JACC Heart Fail. 2025 Oct 14:102718. doi: 10.1016/j.jchf.2025.102718. Epub ahead of print. PMID: 41099687.

Cardiogenic shock & mechanical circulatory support

Outcomes of patients supported on Impella 5.5 for more than 14 days: A Cardiogenic Shock Working Group registry analysis

Kanwar MK, Uriel N, Carnicelli A, John K, Li S, Kong C, Zweck E, Sinha SS, Ton VK, Garan AR, Kataria R, Abraham J, Hernandez-Montfort J, Burkhoff D; CSWG Academic Research Consortium; Kapur NK. Outcomes of patients supported on Impella 5.5 for more than 14 days: A Cardiogenic Shock Working Group registry analysis. J Heart Lung Transplant. 2025 Oct;44(10):1583-1594. doi: 10.1016/j.healun.2025.05.017. Epub 2025 Jun 29. PMID: 40592372.


Impact of comorbidity burden on outcome in patients with cardiogenic shock: A Cardiogenic Shock Working Group analysis

Sundermeyer J, Li S, Ton VK, Kataria R, Zweck E, John K, Kanwar MK, Hernandez-Montfort J, Sinha SS, Garan AR, Abraham J, Blumer V, Kochar A, Ranganathan K, Hickey GW, Pahuja M, Lundgren S, Nathan S, Vorovich E, Hall S, Khalife W, Schwartzman A, Kim J, Vishnevsky OA, Fried J, Farr M, Mishkin J, Chang IH, Ilonze O, Arias A, Nakata J, Marbach J, Bezerra H, Gage A, Wald J, Thomas S, Rahman F, Masoumi A, Afsal A, Gohar S, Goodman R, Walec KD, Natov P, Li B, Sangal P, Kong Q, Zazzali P, Harwani NM, Vallabhajosyula S, Bhimaraj A, Mahr C, Burkhoff D, Kapur NK. Impact of comorbidity burden on outcome in patients with cardiogenic shock: A Cardiogenic Shock Working Group analysis. Eur J Heart Fail. 2025 Sep 16. doi: 10.1002/ejhf.70017. Epub ahead of print. PMID: 40956069.


Liberal or restrictive transfusion for veno-arterial extracorporeal membrane oxygenation patients: a target trial emulation using the OBLEX study data

Thao LTP, Buscher H, Nguyen TL, Martucci G, Gratz J, Trummer G, Schmidt M, Gautier M, Serra A, Takeda K, Pooth JS, Rahn K, Geismann F, Lubnow M, Retter A, Nair P, Vlok R, Siriwardena M, Winearls J, Walsham J, Gattas D, Aneman A, Fulcher B, Newman S, Reynolds C, Arcadipane A, Shekar K, Hodgson C, Pellegrino V, Mueller T, Brodie D, McQuilten Z; International ECMO Network (ECMONet). Liberal or restrictive transfusion for veno-arterial extracorporeal membrane oxygenation patients: a target trial emulation using the OBLEX study data. Crit Care. 2025 Aug 18;29(1):360. doi: 10.1186/s13054-025-05606-1. PMID: 40826421; PMCID: PMC12359932.


Impella 5.5 use in women: A multicenter study 

Asher M, Rekhtman D, Iyengar A, DePaolo J, Song C, Feng I, Morganroth E, Dardik G, Shin M, Weingarten N, Brown A, Wald J, Biscotti M, Takeda K, Cevasco M. Impella 5.5 use in women: A multicenter study. JHLT Open. 2025 Jul 10;9:100341. doi: 10.1016/j.jhlto.2025.100341. PMID: 40778211; PMCID: PMC12329075.


Unfractionated heparin monitoring by anti-factor Xa versus activated partial thromboplastin time strategies during venoarterial extracorporeal life support

Feng I, Powley TR, Yang CG, Kurlansky PA, Sutherland LD, Hastie JM, Kaku Y, Fried JA, Takeda K. Unfractionated heparin monitoring by anti-factor Xa versus activated partial thromboplastin time strategies during venoarterial extracorporeal life support. Perfusion. 2025 Oct;40(7):1575-1584. doi: 10.1177/02676591241309500. Epub 2024 Dec 26. PMID: 39724911.
 

Comparison of Heart Failure Cardiogenic Shock Patients with Axillary and Femoral Intra-aortic Balloon Pump: Cardiogenic Shock Working Group report

Bhimaraj A, Garan AR, Kong Q, Kim JU, Pahuja M, Kochar A, Narayangowda S, Li B, Li S, Sinha SS, Hickey GW, Kataria R, Ton VK, Lundgren S, Nathan S, Vorovich E, Hall S, Khalife W, Schwartzman A, Vishnevsky OA, Zweck E, Fried J, Farr MJ, Mahr C, Mishkin J, Chiang IH, Ilonze O, Arias A, Marbach J, Bezerra H, Sangal P, Walec KD, Zazzali P, Harwani NM, Blumer V, John K, Hernandez-Montfort J, Abraham J, Burkhoff D, Kanwar MK, Kapur NK. Comparison of Heart Failure Cardiogenic Shock Patients with Axillary and Femoral Intra-aortic Balloon Pump: Cardiogenic Shock Working Group report. J Card Fail. 2025 Aug 20:S1071-9164(25)00364-1. doi: 10.1016/j.cardfail.2025.07.020. Epub ahead of print. PMID: 40846302.


Early Extracorporeal Membrane Oxygenation Initiation May Improve Outcomes in Select Patients With Primary Pulmonary Hypertension: An Extracorporeal Life Support Organization Registry Analysis

Smood B, Vasquez CR, Olia SE, Han JJ, Iyengar A, Patrick WL, Helmers MR, Kelly JJ, Richards T, Usman A, Cantu E 3rd, Takeda K, Langer N, Cevasco M. Early Extracorporeal Membrane Oxygenation Initiation May Improve Outcomes in Select Patients With Primary Pulmonary Hypertension: An Extracorporeal Life Support Organization Registry Analysis. ASAIO J. 2025 Aug 1;71(8):611-620. doi: 10.1097/MAT.0000000000002390. Epub 2025 Feb 18. PMID: 39963975; PMCID: PMC12310370.

Left ventricular assist device (LVAD)

Implantable Cardioverter-Defibrillators and Cardiovascular Resynchronization Therapy with Left Ventricular Assist Devices A MOMENTUM 3 Trial Analysis 

Sayer G, Ahmed MM, Mehra MR, Gosev I, Vidula H, Devore AD, Horstmanshof DA, Cleveland JC Jr, Stewart GC, Slaughter MS, Mudy K, Wang A, Uriel N. Implantable Cardioverter-Defibrillators and Cardiovascular Resynchronization Therapy with Left Ventricular Assist DevicesA MOMENTUM 3 Trial Analysis. J Card Fail. 2025 Oct;31(10):1548-1557. doi: 10.1016/j.cardfail.2024.12.011. Epub 2025 Jan 22. PMID: 39855458.


Angiotensin-Neprilysin Inhibition and Left Ventricular Assist Device Therapy: Primary Results of the ENVAD-HF Trial

Cikes M, Brugts JJ, Claggett B, Jorde UP, Milicic D, Planinc I, Ruschitzka F, Uriel N, Kulac I, Jakus N, Loncaric F, Puskaric F, Sipus D, Gasparovic H, Rubis P, van Laake LW, Rudez I, Hegarova M, Sestan G, Wisniowska-Smialek S, Wierzbicki K, Mehra MR, Solomon SD. Angiotensin-Neprilysin Inhibition and Left Ventricular Assist Device Therapy: Primary Results of the ENVAD-HF Trial. JACC Heart Fail. 2025 Nov;13(11):102657. doi: 10.1016/j.jchf.2025.102657. Epub 2025 Aug 31. PMID: 40892548.


Long-term outcomes of tricuspid valve repair or replacement in patients with a continuous-flow left ventricular assist device 

Shah S, Wang C, Camacho GA, Miskovsky E, Yang C, Diaz AR, Chang-Huang S, Vinogradsky A, Yuzefpolskaya M, Colombo PC, Sayer G, Uriel N, Naka Y, Kurlansky P, Takeda K. Long-term outcomes of tricuspid valve repair or replacement in patients with a continuous-flow left ventricular assist device. J Thorac Cardiovasc Surg. 2025 Sep 5:S0022-5223(25)00742-1. doi: 10.1016/j.jtcvs.2025.08.039. Epub ahead of print. PMID: 40915411.


Contemporary Outcomes of Ventricular Tachycardia Ablation in Left Ventricular Assist Device Therapy: A Meta-Analysis

Barrera N, Kushnir Y, Solorzano M, Gallegos-Koyner F, Lynch PT, Queiroga F, Giorgi J, Brigido ARD, de Carvalho GD, Chelu MG, Colombo PC, D'Avila A. Contemporary Outcomes of Ventricular Tachycardia Ablation in Left Ventricular Assist Device Therapy: A Meta-Analysis. J Cardiovasc Electrophysiol. 2025 Oct 13. doi: 10.1111/jce.70136. Epub ahead of print. PMID: 41078026.

 

Primary Graft Dysfunction in Patients Supported With Durable Left Ventricular Assist Devices Before Heart Transplantation

Truby LK, Moayedi Y, Signorile M, Steve Fan CP, Foroutan F, Ross H, Guzman-Bofarull J, Lerman JB, DeVore AD, Hall S, Takeda K, Chih S, Rodenas-Alesina E, Rivas-Lasarte M, Han J, Kim G, Moayedifar R, Couto-Mallon D, Luikart H, Henricksen E, Sabatino M, Tremblay-Gravel M, Noly PE, Miller R, Potena L, Crespo-Leiro M, Segovia-Cubero J, Farrero M, Zuckermann A, Khush KK, Farr M. Primary Graft Dysfunction in Patients Supported With Durable Left Ventricular Assist Devices Before Heart Transplantation. JACC Heart Fail. 2025 Nov;13(11):102618. doi: 10.1016/j.jchf.2025.102618. Epub 2025 Oct 11. PMID: 41074902.


Impact of Preoperative Temporary Mechanical Circulatory Support on Durable LVAD Outcomes: An Analysis of The Society of Thoracic Surgeons National Intermacs Database

Kanwar MK, Shah P, Cascino T, Grinstein J, Goldstein D, Hernandez-Montfort J, Li S, Uriel N, Molina E, Cantor R, Komanduri B, Pagani FD, Kirklin JK. Impact of Preoperative Temporary Mechanical Circulatory Support on Durable LVAD Outcomes: An Analysis of The Society of Thoracic Surgeons National Intermacs Database. JACC Heart Fail. 2025 Nov;13(11):102671. doi: 10.1016/j.jchf.2025.102671. Epub 2025 Oct 8. PMID: 41193107.