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Vivette D. D'Agati, MD

Anatomic Pathology (Board Certified, Primary Specialty)
One of America's Top Doctors
Rated one of New York Magazine's Best Doctors

Biography

I direct one of the largest renal pathology laboratories in the country, which processes approximately 4800 renal biopsies annually. My major research interests are mechanisms of glomerular and tubulointerstitial injury in podocytopathies, immune mediated glomerulonephritis, and toxic tubulopathies. I am interested in how pathologic forms of injury manifest clinically, the pathogenetic mechanisms governing distinct morphologic patterns of injury, and how disease biomarkers can inform treatment and outcome in the individual patient. My basic research has focused primarily on mechanisms of podocyte dysregulation, injury and depletion in primary and secondary forms of FSGS and how such dysregulation promotes progressive CKD. My work in animal models has characterized molecular mechanisms of podocyte injury in HIVAN, primary FSGS and diabetic nephropathy.

My large renal biopsy practice has facilitated my group’s discovery and characterization of new glomerulopathies and emerging forms of drug toxicity, such as IgA-dominant post-staphylococcal glomerulonephritis, proliferative glomerulonephritis with monoclonal IgG deposits, smoking-related glomerulopathy, phosphate nephropathy and the nephrotoxicity of bisphosphonates and anabolic steroids. My laboratory’s discovery of CKD following phosphate-based bowel cleansing for screening colonoscopy and FSGS following anabolic steroid abuse were the subject of feature articles in the Science and Sports sections of the New York Times.

In addition to my clinical practice and research, I am deeply committed to education. I have published over 400 peer-reviewed papers and 80 book chapters, and have co-edited 6 textbooks of renal pathology, including the latest edition of Heptinstall’s Pathology of the Kidney. For the past 3 decades, I have organized and directed the annual Columbia postgraduate course “Renal Biopsy in Medical Diseases of the Kidney”, which is attended by approximately 200 international registrants per year. I lecture regularly in symposia and courses at annual meeting of the ASN, WCN and USCAP and have trained approximately 20 fellows, many of whom now direct their own renal pathology laboratories at major medical centers.

Email: vdd1@cumc.columbia.edu

Area of Expertise

Please contact the doctor's office to verify that your insurance is accepted.

Aetna [EPO, HMO, Medicare Managed Care, NY Signature, POS, PPO, Signature Administrators, Student Health]

Cigna [EPO, Great West, HMO, POS, PPO]

Emblem/GHI [HMO, Medicare Managed Care, PPO]

Emblem/HIP [ConnectiCare, EPO, Essential Plan, HMO, Medicaid Managed Care, Medicare Managed Care, POS, PPO, Select Care (Exchange), Vytra]

Empire Blue Cross Blue Shield [Blue Priority, EPO, HMO, Medicare (Mediblue), NYP Employee Plan, Pathway (Exchange), POS, PPO]

Local 1199 [Local 1199]

Multiplan [Multiplan]

Oxford Health Plans [Freedom, Liberty, Medicare Managed Care]

UnitedHealthcare [Columbia University Employee Plan, Compass (Exchange), EPO, Essential Plan, HMO, Medicaid (Community Plan), Medicare Managed Care, POS, PPO]

Education

New York University School of Medicine

Residency: Columbia Presbyterian Medical Center

Fellowship: National Kidney Foundation

Publications

D'Agati VD, Kaskel FJ, Falk RJ. Focal segmental glomerulosclerosis. N Engl J Med. 2011 Dec 22;365(25):2398-411.PMID: 22187987

D'Agati VD, Chagnac A, de Vries AP, Levi M, Porrini E, Herman-Edelstein M, Praga M: Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis, Nat Rev Nephrol 12: 453-471, 2016.

Kambham N, Markowitz GS, Valeri AM, Lin J, D'Agati VD. Obesity-related glomerulopathy: an emerging epidemic. Kidney Int. 2001 Apr;59(4):1498-509. PMID: 11260414

D'Agati VD, Fogo AB, Bruijn JA, Jennette JC. Pathologic classification of focal segmental glomerulosclerosis: a working proposal. Am J Kidney Dis. 2004 Feb;43(2):368-82. PMID: 14750104

D'Agati VD, Alster JM, Jennette JC, Thomas DB, Pullman J, Savino DA, Cohen AH, Gipson DS, Gassman JJ, Radeva MK, Moxey-Mims MM, Friedman AL, Kaskel FJ, Trachtman H, Alpers CE, Fogo AB, Greene TH, Nast CC.  Association of histologic variants in FSGS clinical trial with presenting features and outcomes. Clin J Am Soc Nephrol. 2013 Mar;8(3):399-406. PMID: 23220425

Nasr SH, Fidler ME, Valeri AM, Cornell LD, Sethi S, Zoller A, Stokes MB, Markowitz GS, D'Agati VD: Postinfectious glomerulonephritis in the elderly. J Am Soc Nephrol. 2011 Jan;22(1):187-95. PMID: 21051737

Nasr SH, Satoskar A, Markowitz GS, Valeri AM, Appel GB, Stokes MB, Nadasdy T, D'Agati VD. Proliferative glomerulonephritis with monoclonal IgG deposits. J Am Soc Nephrol. 2009 Sep;20(9):2055-64. PMID: 19470674

Markowitz GS, Stokes MB, Radhakrishnan J, D'Agati VD. Acute phosphate nephropathy following oral sodium phosphate bowel purgative: an underrecognized cause of chronic renal failure. J Am Soc Nephrol. 2005 Nov;16(11):3389-96. PMID: 16192415

Herlitz LC, Markowitz GS, Farris AB, Schwimmer JA, Stokes MB, Kunis C, Colvin RB, D'Agati VD. Development of focal segmental glomerulosclerosis after anabolic steroid abuse. J Am Soc Nephrol. 2010 Jan;21(1):163-72.PMID: 19917783

Hodgin JB, Borczuk AC, Nasr SH, Markowitz GS, Nair V, Martini S, Eichinger F, Vining C, Berthier CC, Kretzler M, D'Agati VD. A molecular profile of focal segmental glomerulosclerosis from formalin-fixed, paraffin-embedded tissue. Am J Pathol. 2010 Oct;177(4):1674-86. PMID: 20847290

Papeta N, Zheng Z, Schon EA, Brosel S, Altintas MM, Nasr SH, Reiser J, D'Agati VD, Gharavi AG. Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice. J Clin Invest. 2010 Nov;120(11):4055-64. PMID: 20978358

Shkreli M, Sarin KY, Pech MF, Papeta N, Chang W, Brockman SA, Cheung P, Lee E, Kuhnert F, Olson JL, Kuo CJ, Gharavi AG, D'Agati VD, Artandi SE. Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling. Nat Med. 2011 Dec 4;18(1):111-9. PMID: 22138751

Daehn I, Casalena G, Zhang T, Shi S, Fenninger F, Barasch N, Yu L, D'Agati V, Schlondorff D, Kriz W, Haraldsson B, Bottinger EP. Endothelial mitochondrial oxidative stress determines podocyte depletion in segmental glomerulosclerosis. J Clin Invest. 2014 Apr;124(4):1608-21.PMID: 24590287

D'Agati V, Suh JI, Carbone L, Cheng JT, Appel G Pathology of HIV-associated nephropathy: a detailed morphologic and comparative study. Kidney Int. 1989 Jun;35(6):1358-70. PMID: 2770114

Marras D, Bruggeman LA, Gao F, Tanji N, Mansukhani MM, Cara A, Ross MD, Gusella GL, Benson G, D'Agati VD, Hahn BH, Klotman ME, Klotman PE. Replication and compartmentalization of HIV-1 in kidney epithelium of patients with HIV-associated nephropathy. Nat Med. 2002 May;8(5):522-6. PMID: 11984599

Professor of Pathology at NewYork-Presbyterian/Columbia University Medical Center

1975 Phi Beta Kappa, Summa cum Laude, Yale College

1979 Alpha Omega Alpha Medical Honor Society, NYU School of Medicine

1993, 2012 Program Committee, American Society of Nephrology

1994-1996 Postgraduate Education Committee, American Society of Nephrology

1996 President, Renal Pathology Society

2000 Jacob Churg Award, Renal Pathology Society

2006 Association of American Physicians

2007 Teacher of the Year, Columbia University Medical School class of 2009

2008 Teacher of the Year, Columbia University Medical School class of 2010

1998-2001 Editorial Board, American Journal of Kidney Diseases

1999-present   Editorial Board, Journal of the American Society of Nephrology

2007-present   Editorial Board, Kidney International