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Timothy Cragin Wang, <span>MD</span>

Timothy Cragin Wang, MD

Gastroenterology (Board Certified, Primary Specialty)
Internal Medicine (Board Certified)
Cancer Care
One of America's Top Doctors

Biography

Dr. Timothy Wang is a leading expert in gastroenterology cancer research and patient care. His research specifically focuses on transgenic/ knockout mice, stem cells, lineage tracing, bone marrow-derived cells, and FACS analysis of immune/epithelial cells in the gut. His laboratory has for decades investigated the molecular mechanisms of gastrointestinal carcinogenesis, and has been continuously funded by the NIH for 29 years and by the NCI for 14 years. His lab has worked for many years on the role of inflammation in promoting gastrointestinal neoplasia, including colon cancer. His research has defined key roles for stromal cells in tumor development, including myeloid cells.

Dr. Wang is the GI Division Chief at Columbia and serves as Co-leader of the Tumor Biology and Microenvironment Program of the Herbert Irving Comprehensive Cancer Center. He also serves as director of the Columbia University NCI U54 Tumor Microenvironment (TMEN) program and directs the Barrett’s Esophageal Translational Research Network (BETRNet) program and the Intestinal Stem Cell Consortium (ISCC) at Columbia.

In addition to his leadership at Columbia, Dr. Wang has served as President of the American Gastroenterology Association (AGA). His work has been recognized with numerous awards, including the Outstanding Investigator Award from the NCI, the Irene and Arthur Fishberg Prize for medical research, the Ruth Leff Siegel Award for pancreatic cancer research, and the William Beaumont Prize in Gastroenterology from the AGA. Over his career, he has organized numerous conferences, including conferences on Gastrin, Regulatory Peptides, AACR Symposium on Gastric Cancer, Tumor Microenvironment, and Keystone Conferences.

Area of Expertise

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Education

Columbia University College of Physicians and Surgeons

Internship: Barnes Jewish Hospital

Residency: Barnes Jewish Hospital

Fellowship: Harvard Hospitals

Publications

  • Wang TC, Cardiff RD, Zuckerberg L, Lees E, Arnold A, and Schmidt EV. (1994) Mammary hyperplasia and carcinoma in MMTV-Cyclin D1 transgenic mice. Nature 369:669-71
  • Fox JG, Beck P, Dangler CA, Whary MT, Wang TC, Shi HN, and Anderson CN. (2000) Concurrent enteric helminth infection modulates inflammation, gastric immune responses, and reduces Helicobacter-induced gastric atrophy. Nature Medicine 6:536-42
  • Houghton J, Stoicov C, Nomura S, Rogers AB, Carlson J, Li H, Cai X, Fox JG, Goldenring JR, Wang TC. (2004) Gastric cancer originating from bone marrow-derived cells. Science 306:1568-71
  • Tu S, Bhagat G, Cui G, Takaishi S, Kurt-Jones EA, Rickman B, Betz KS, Penz-Oesterreicher M, Bjorkdahl O, Fox JG, Wang TC. (2008) Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. Cancer Cell 14:408-19
  • Takaishi S, Okumura T, Tu S, Wang SS, Shibata W, Vigneshwaran R, Gordon SA, Shimada Y, Wang TC.
  • (2009) Identification of gastric cancer stem cells using the cell surface marker CD44. Stem Cells 27:1006-20
  • Jin G, Ramanathan V, Baik GH, Wang SSW, Tu S, Pritchard DM, Varro A, Shulkes A, Wang TC. (2009 ) Inactivation of the cholecystokinin-2 receptor inhibits progastrin-dependent crypt fission, colonic proliferation and colorectal cancer. Journal of Clinical Investigation Sept: