Steven L. Spitalnik, <span>MD</span>

Steven L. Spitalnik, MD

Pathology-Anatomic/Pathology-Clinical (Board Certified, Primary Specialty)


Dr. Steven Spitalnik, MD is the Co-Director of the Laboratory of Transfusion Biology, which pursues NIH-funded research aimed at improving transfusion practice. Dr. Spitalnik is a Professor of Pathology and Cell Biology and the Vice-Chairman of Laboratory Medicine at Columbia University Medical Center (CUMC). As the Medical Director of the Clinical laboratories on the CUMC campus of the New York-Presbyterian Hospital, he coordinates the clinical service, educational, and scholarly activities of the Division. He has been a Member of Scientific and Medical Advisory Board at Theranos, Inc. since April 7, 2016. He is a long-standing member of the Academy of Clinical Laboratory Physicians & Scientists, serving as its President in 2002-03 and, in 2005, receiving its Gerald T. Evans Award for outstanding leadership and service to the Academy. In addition to being board certified in both Anatomic and Clinical Pathology, Dr. Spitalnik is a member of the Editorial Boards of Transfusion, Transfusion Medicine Reviews, and Current Opinion in Hematology, and is the lead author of Clinical Pathology Board Review.



It Happened Here: Dr. Charles Drew - NewYork Presbyterian Health Matters

TV Interview

Interview about hemolytic disease of the newborn on Italian TV (Rai2)

Area of Expertise

Please contact the doctor's office to verify that your insurance is accepted.


University of Chicago Pitzker School of Medicine

Internship: University of Rochester

Residency: University of Rochester

Fellowship: University of Rochester

Fellowship: National Institutes of Health


Zimring JC, Smith N, Stowell SR, Johnsen JM, Bell LN, Francis RO, Hod EA, Hendrickson JE, Roback JD, Spitalnik SL. Strain-specific red blood cell storage, metabolism, and eicosanoid generation in a mouse model. Transfusion 54:137-148, 2014.

LaRocca TJ, Stivison EA, Hod EA, Spitalnik SL, Cowan PJ, Randis TM, Ratner AJ. Human-specific bacterial pore-forming toxins induce programmed necrosis in erythrocytes. mBio 5(5):e01251-14, 2014.

Prestia K, Bandyopadhyay S, Slate A, Francis RO, Francis KP, Spitalnik SL, Fidock DA, Brittenham GM, Hod EA. Transfusion of stored blood impairs host defenses against Gram-negative pathogens in mice. Transfusion 54:2842-2851, 2014.

Wojczyk BS, Kim N, Bandyopadhyay S, Francis RO, Zimring JC, Hod EA, Spitalnik SL. Macrophages clear refrigerator storage-damaged RBCs and subsequently secrete cytokines in vivo, but not in vitro, in a murine model. Transfusion 54:3186-3197, 2014.

LaRocca T, Stivison E, Mal-Sarkar T, Hooven T, Hod E, Spitalnik SL, Ratner A. CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis. Cell Death and Disease 6:e1773; doi:10.1038/cddis.2015.135, 2015

Xu JZ, Francis RO, Lerebours Nadal LE, Shirazi M, Jobanputra V, Hod EA, Jhang JS, Stotler BA, Spitalnik SL, Nicholas SW. G6PD Deficiency in an HIV Clinic Setting in the Dominican Republic. American Journal of Tropical Medicine and Hygiene 93:722-729, 2015.

Waterman HR, Kapp LM, Howie HL, Hod EA, Spitalnik SL, Zimring JC. Analysis of 24-h recovery of transfused stored RBCs in recipient mice of distinct genetic backgrounds. Vox Sanguinis 109:148-154, 2015.

L’Acqua C, Bandyopadhyay S, Francis RO, McMahon DJ, Nellis M, Sheth S, Kernie SG, Brittenham GM, Spitalnik SL, Hod EA. Red blood cell transfusion is associated with increased hemolysis and an acute phase response in a subset of critically ill children. American Journal of Hematology 90:915-920, 2015.

Zimring JC, Spitalnik SL. Pathobiology of haemolytic transfusion reactions. Annual Review of Pathology 10:83-110, 2015.

Spitalnik SL, Triulzi D, Devine DV, Dzik WH, Eder AF, Gernsheimer T, Josephson CD, Kor DJ, Luban NLC, Roubinian NH, Mondoro T, Welniak LA, Zou S, Glynn S for the State of the Science in Transfusion Medicine Working Groups. 2015 Proceedings of the National Heart, Lung, and Blood Institute’s State of the Science in Transfusion Medicine Symposium. Transfusion55:2282-2290, 2015.

Calabro S, Gallman A, Gowthaman U, Liu D, Chen P, Liu J, Krishnaswamy JK, Nascimento MSL, Xu L, Patel SR, Williams A, Tormey CA, Hod EA, Spitalnik SL, Zimring JC, Hendrickson JE, Stowell SR, Eisenbarth SC. Bridging channel dendritic cells induce immunity to transfused red blood cells, Journal of Experimental Medicine 213:887-896, 2016.

Professor of Pathology & Cell Biology

1974  Phi Beta Kappa

1974  Honors in Mathematics, Princeton University

1981, 1982, 1983  Young Investigator Award, Academy of Clinical Laboratory Physicians and Scientists

1987-1990  Junior Faculty Research Award, American Cancer Society

1987-1992  FIRST Award, National Institutes of Health

1989-1992  Mallinckrodt Scholar

1989  Class of `92 Commendation for Outstanding Teaching, University of Pennsylvania

1990  Class of `93 Commendation for Outstanding Teaching, University of Pennsylvania

1991  Dean's Award for Excellence in Basic Science Teaching, University of Pennsylvania

1991  US-Poland Individual Health Scientist Exchange Program Fellowship, Fogarty International Center

1992  Class of `95 Commendation for Outstanding Teaching, University of Pennsylvania

1994  Elected to American Society for Clinical Investigation

1995  Peter C. Nowell Teaching Award, University of Pennsylvania

1995  FASEB Visiting Scientist; Barry University, Miami Shores, FL. The role of glycosylation of ß-amyloid precursor protein in the pathogenesis of Alzheimer's disease.

1996  Penn Pearls Teaching Award, University of Pennsylvania

1996  Leonard Berwick Memorial Teaching Award, University of Pennsylvania

1996  Class of `99 Commendation for Outstanding Teaching, University of Pennsylvania

1997  Class of `00 Commendation for Outstanding Teaching, University of Pennsylvania

1997  Annual Meeting of the American Association of Blood Banks, Denver, CO. Workshop organizer and speaker: A Transfusion Medicine Primer

1998  Christian R. and Mary F. Lindback Foundation Teaching Award, University of Pennsylvania

1999  Sherwood Smith Memorial Lectureship, New York Association of Blood Banks Annual Meeting, Rochester, NY. The impact of molecular biology on the practice of transfusion medicine.

2002  Faculty Mentor Award, 4th Annual Marvin J. Hoffman Day, University of Rochester

2002  Short course on the biochemistry of the red blood cell membrane, Annual Meeting of the American Association of Blood Banks, Orlando, FL. Glycobiology of the red blood cell membrane

2002  Short course on human carbohydrate blood group antigens, Annual Meeting of the American Association of Blood Banks, Orlando, FL. The Lewis blood group system

2003  Eric A. Schenk Award for Excellence in Teaching, University of Rochester

2005  Gerald T. Evans Award for outstanding leadership and service to the academy, Academy of Clinical Laboratory Physicians & Scientists

2013  Graham A. Jamieson Memorial Lectureship, American Red Cross

2013  Emily Cooley Award and Lectureship, American Association of Blood Banks

2016  Elected to Hall of Fame, National Blood Foundation

2016  Inaugural Class, Academy of Clinical Mentoring and Excellence, Columbia University College of Physicians & Surgeons