Cancer Prevention Clinical Trials

Listed below are cancer prevention clinical trials. If you are interested in learning more about a trial, access the National Cancer Institute (NCI) web site for additional information. All clinical trials are part of the NCI's PDQ® Cancer Clinical Trials Registry located at //

Breast | Gastrointestinal | Gynecologic | Head and Neck/Oral | Lung | Prostate and Other Urological Cancers | Smoking Cessation | Other Cancer Prevention Clinical Trials


  • Alendronate Sodium in Preventing Breast Cancer in Premenopausal Patients Undergoing Risk-Reduction Surgery [View]
  • Curcumin in Reducing Inflammatory Changes in Breast tissue in Obese Patients At High Risk for breast Cancer [View]
  • Energy Balance Interventions in Increasing Physical Activity in BRCA-Positive Patients, Lynch Syndrome-Positive Patients, or High-Risk Family Members [View]
  • Exercise Intervention in Preventing Breast Cancer in African-American Patients With Metabolic Syndrome [View]
  • Metformin Hydrochloride in Reducing Obesity-Associated Breast Cancer Risk [View]
  • Metformin Hydrochloride vs. Placebo in Overweight or Obese Patients at Elevated Risk for Breast Cancer [View]
  • Metformin Hydrochloride in Preventing Breast Cancer in Patients with Atypical Hyperplasia or In Situ Breast Cancer [View]
  • NSAID Effects on Clinical and Imaging Breast Biomarkers [View]
  • Sirolimus in Preventing Invasive Breast Cancer in Patients with Ductal Carcinoma In Situ or Atypical Ductal Breast Hyperplasia [View]


  • Acetylsalicylic Acid in Preventing Disease Recurrence in Patients with Barrett’s Esophagus after Successful Elimination by Radiofrequency Ablation [View]
  • Aspirin in Preventing Colorectal Cancer in Patients Who Have Undergone Colonoscopy and Adenoma Removal [View]
  • Berberine Chloride in Treating Patients with Ulcerative Colitis in Remission [View]
  • Curcumin in Preventing Gastric Cancer in Patients with Chronic Atrophic Gastritis or Gastric Intestinal Metaplasia [View]
  • Eflornithine and/or Sulindac in Preventing Recurrence of High-Risk Adenomas and Second Primary Disease in Patients with Stage 0-III Colon or Rectal Cancer [View]
  • Erlotinib Hydrochloride in Preventing Liver Cancer in Patients with Cirrhosis of the Liver Undergoing Surgery [View]
  • Erlotinib Hydrochloride in Reducing Duodenal Polyp Burden in Patients with Familial Adenomatous Polyposis at Risk of Developing Colon Cancer [View]
  • Naproxen in Preventing DNA Mismatch Repair Deficient Colorectal Cancer in Patients with Lynch Syndrome [View]
  • Narrative or Fact-Based Videos in Increasing Colorectal Cancer Screenings in African American Communities [View]
  • Topical or Ablative Treatment in Preventing Anal Cancer in Patients with HIV and Anal High-Grade Squamous Intraepithelial Lesions [View]


  • High-Resolution Microendoscopy in Preventing Cervical Cancer in Patients with an Abnormal PAP Smear [View]
  • Levonorgestrel Intrauterine Device in Preventing Ovarian Cancer in Patients Undergoing Surgical Removal of the Fallopian Tubes and Ovaries [View]
  • Recombinant Human Papillomavirus Nonavelent Vaccine in Preventing Human Papilloma Virus in Younger Healthy Participants [View]
  • Surgery in Preventing Ovarian Cancer in Patients with Genetic Mutations [View]
  • Vaccine Therapy with or without imiquimod in Treating Patients with High-Grade Cervical Intraepithelial Neoplasia [View]

Head and Neck/Oral

  • Bupropion Hydrochloride or Patients’ Choice for Smoking Cessation in Patients with Squamous Cell Head and Neck Cancer Undergoing Radiation Therapy with or without Chemotherapy [View]
  • Defined Green Tea Catechin Extract and Erlotinib Hydrochloride in Treating Patients with Premalignant Lesions or Previously Treated Early Stage Squamous Cell Cancer of the Head and Neck [View]
  • Effect of Black Raspberry Phytochemicals on Oral Microbiome in Current Smokers and Non-smokers [View]
  • Metformin Hydrochloride in Preventing Oral Cancer in Patients with an Oral Premalignant Lesion [View]
  • Vandetanib in Preventing Head and Neck Cancer in Patients with Precancerous Head and Neck Lesions [View]


  • Acetylsalicylic Acid Compared to Placebo in Treating High-Risk Patients with Subsolid Lung Nodules [View]
  • Aspirin and Zileuton and Biomarker Expression in Nasal Tissue of Current Smokers [View]
  • Calcitriol in Preventing Lung Cancer in High-Risk Patients [View]
  • Cholecalciferol Supplementation in Preventing Lung Cancer in D Vitamin-Deficient Patients with Chronic Obstructive Pulmonary Disease [View]
  • Iloprost in Preventing Lung Cancer in Former Smokers [View]
  • Phenethyl Isothiocyanate in Preventing Lung Cancer in Smokers [View]

Prostate and Other Urological Cancers

  • Low-Fat Diet and Fish Oil in Men on Active Surveillance for Prostate Cancer [View]

Smoking Cessation

  • Behavioral Activation Therapy and Nicotine Replacement Therapy in Increasing Smoking Cessation [View]
  • Behavioral Counseling and Nicotine Replacement Therapy or Varenicline in Helping Smokers Quit [View]
  • Effectiveness of Smoking Cessation Program in Improving Abstinence and Cost Outcomes in Cigarette Smokers [View]
  • Informing Tobacco Treatment Guidelines for African American Non-Daily Smokers [View]
  • Nicotine Delivery from Novel Non-Tobacco Electronic System in Smokers [View]
  • Proactive Counseling and Nicotine Replacement Therapy in Changing the Default for Tobacco Treatment in Smokers [View]
  • Smoking-cessation: A Spanish-Language Clinical Trial [View]
  • Smoking-cessation Self-Help for Dual Users of Tobacco Cigarettes and E-Cigarettes [View]
  • Varenicline and Nicotine Replacement Therapy for Initial Smoking Cessation and Treatment in Smokers [View]

Other Cancer Prevention Clinical Trials

  • Carrageenan-Containing Gel in Reducing the Rate of HPV Infection in Healthy Participants [View]
  • Eat, Move, Live Intervention in Reducing Chronic Disease Risk in Medically Vulnerable Communities [View]
  • Energy Balance Interventions in Increasing Physical Activity in BRCA-Positive Patients, Lynch Syndrome-Positive Patients, CLL Survivors or High-Risk Family Members [View]
  • Mobile Health Intervention in Increasing HPV Vaccine Coverage among Young Adult Gay and Bisexual Men [View]
  • Vaccine Therapy in Preventing Human Papillomavirus Infection in Younger Cancer Survivors [View]