Kelley Yan, MD, PhD

Gastroenterology (Board Certified, Primary Specialty)
Internal Medicine (Board Certified)
Office Phone: (212) 305-1021

Area of Expertise

Please contact the doctor's office to verify that your insurance is accepted.

Aetna [EPO, HMO, Medicare Managed Care, NY Signature, POS, PPO, Signature Administrators, Student Health]

Affinity [Access (Exchange), Essential Plan, Medicaid Managed Care, Medicare Managed Care]

Amida Care [Special Needs Plan]

Cigna [EPO, Great West, HMO, POS, PPO]

Emblem/GHI [HMO, Medicare Managed Care, PPO]

Emblem/HIP [ConnectiCare, EPO, Essential Plan, HMO, Medicaid Managed Care, Medicare Managed Care, POS, PPO, Select Care (Exchange), Vytra]

Empire Blue Cross Blue Shield [Blue Priority, EPO, HMO, Medicare (Mediblue), NYP Employee Plan, Pathway (Exchange), POS, PPO]

Empire Blue Cross Blue Shield HealthPlus [Child/Family Health Plus, Essential Plan, Medicaid Managed Care]

Fidelis Care [Child/Family Health Plus, Medicaid Managed Care, Medicare Managed Care]

Healthfirst [Child/Family Health Plus, Medicaid Managed Care, Medicare Managed Care]

Local 1199 [Local 1199]

MagnaCare [MagnaCare]

Multiplan [Multiplan]

Oxford Health Plans [Freedom, Liberty, Medicare Managed Care]

POMCO [POMCO]

UnitedHealthcare [Columbia University Employee Plan, Compass (Exchange), EPO, Essential Plan, HMO, Medicaid (Community Plan), Medicare Managed Care, POS, PPO]

VNSNY CHOICE [Medicare Managed Care, SelectHealth]

WellCare [Medicaid Managed Care, Medicare Managed Care]

Education

MD, Mount Sinai School of Medicine

Internship: Stanford University Hospital and Clinics

Residency: Stanford University Hospital and Clinics

Fellowship: Stanford University Hospital and Clinics

Publications

21. Yan KS, Janda CY, Chang J, Zheng GXY, Larkin KA, Luca VC, Chia LA, Mah AT, Han A, Terry JM, Ootani A, Roelf K, Lee M, Yuan J, Li X, Bolen CR, Wilhelmy J, Davies PS, Ueno H, von Furstenberg RJ, Belgrader P, Ziraldo SB, Ordonez H, Henning SJ, Wong MH, Snyder MP, Weissman IL, Hsueh AJ, Mikkelsen TS, Garcia KC, & Kuo CJ.  Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal.   Nature. 2017 May 11;545(7653):238-242.  PMID: 28467820

20. Janda CY*, Dang LT*, You C, Chang J, de Lau W, Zhong ZA, Yan KS, Marecic O, Siepe D, Li X, Moody JD, Williams BO, Clevers H, Piehler J, Baker D, Kuo CJ, & Garcia KC. Surrogate Wnt ligands that phenocopy canonical Wnt and β-catenin signalling.   Nature. 2017 May 11;545(7653):234-237.  PMID: 28467818

19. Mah, AT, Yan KS, & Kuo CJ.  Wnt pathway regulation of intestinal stem cells.   J. Physiol. 594(17):4837-47 (2016).  PMID 27581568

18. Yan KS & Kuo CJ.  Ascl2 reinforces intestinal stem cell identity.  Cell Stem Cell 16(2):105-6 (2015). PMID: 25658363

17. Chan CK, Seo EY, Chen JY, Lo D, McArdle A, Sinha R, Tevlin R, Seita J, Vincent-Tompkins J, Wearda T, Lu WJ, Senarath-Yapa K, Chung MT, Marecic O, Tran M, Yan KS, Upton R, Walmsley GG, Lee AS, Sahoo D, Kuo CJ, Weissman IL, & Longaker MT.  Identification and specification of the mouse skeletal stem cell.   Cell 160(1-2):285-98 (2015). PMID 25594184 (*Faculty of 1000 recommended)

16. DiMarco RL, Su J, Yan KS, Dewi R, Kuo CJ & Heilshorn SC.  Engineering of Three-Dimensional Microenvironments to Promote Contractile Behavior in Primary Intestinal Organoids. Integrative Biology 6(2):127-42 (2014). PMID:24343706

15. Lim X, Tan SH, Koh WL, Chau RM, Yan KS, Kuo CJ, van Amerongen R, Klein AM & Nusse R. Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling.  Science 342 (6163):1226-30 (2014). PMID:  24311688 (*Faculty of 1000 recommended)

14. Magness ST, Puthoff BJ, Crissey MA, Dunn JC, Henning SJ, Houchen CW, Kaddis JS, Kuo CJ, Li L, Lynch JP, Martin MG, May RJ, Niland JC, Olack B, Qian D, Stelzner M, Swain J, Wang F, Wang J, Wang X, Yan K, Yu J & Wong MH. A multi-center study to standardize reporting and analyses of fluorescence-activated cell sorted murine intestinal epithelial cells.  Am J Physiol Gastrointest Liver Physiol 305 (8): G542-51 (2013).  PMID: 23928185

13. Barry ER, Morikawa T, Butler BL, Shrestha K, de la Rosa R, Yan KS, Fuchs CS, Magness ST, Smits R, Ogino S, Kuo CJ & Camargo FD.  Restriction of intestinal stem cell expansion and the regenerative response by YAP.  Nature 493 (7430):106-10 (2013). PMID:23178811 (*Faculty of 1000 recommended)

12. Yan KS, Chia LA, Li X, Ootani A, Su J, Lee JY, Su N, Luo Y, Heilshorn SC, Amieva MR, Sangiorgi E, Capecchi MR & Kuo CJ. The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations.  Proc Natl Acad Sci 109(2):466-471 (2012).  PMID 22190486 (*Faculty of 1000 recommended)

11. Kaltenbach T, Leung C, Wu K, Yan K, Friedland S & Soetikno R.  Use of the Colonoscope Training Model with the Colonoscope 3D Imaging Probe Improved Trainee Colonoscopy Performance: A Pilot Study.  Dig Dis Sci 56(5), 1496-1502 (2011).  PMID: 21409379

10. Zeng L, Zhang Q, Yan K & Zhou MM.  Structural Insights into piRNA recognition by the human PIWI-like 1 PAZ domain.  Proteins 79(6), 2004-2009 (2011).  PMID: 21465557

9.   Yan KS & Pasricha PJ. Acting in Good Taste: Nutrient Sensors in the Gut.  Gut 58(7):897-898 (2009).  PMID: 19520884

8.   Yan KS, Yan S, Farooq A, Han A, Zeng L & Zhou MM.  Structure and Conserved RNA Binding of the PAZ Domain. Nature 426, 468-474 (2003). PMID: 14615802 (*Faculty of 1000 recommended)

7.   Farooq A, Zeng L, Yan KS, Ravichandran KS & Zhou MM. Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc. Structure 11, 905-913 (2003).  PMID: 12906822

6.   Yan KS & Zhou MM. Examining Both Sides of a Janus PTB Domain. Structure 11, 482-484 (2003).  PMID: 12737812

5.   Yan KS & Zhou MM. TAGging the Target for Damage Control. Nature Structural Biology 9, 638-640 (2002).  PMID: 12198481

4.   Yan KS, Kuti M & Zhou MM. PTB or Not PTB—That is the Question. FEBS Letters 513, 67-70 (2002).  PMID: 11911882

3.   Yan KS, Kuti M, Yan S, Mujtaba S, Farooq A, Goldfarb MP & Zhou MM. FRS2 PTB Domain Conformation Regulates Interactions with Divergent Neurotrophic Receptors. Journal of Biological Chemistry 277, 17088-17094 (2002).  PMID: 11877385

 2.  Dhalluin C, Yan KS, Plotnikova O, Zeng L, Goldfarb MP & Zhou MM. 1H, 13C and 15N Resonance Assignments of the SNT PTB Domain in Complex with FGFR1 Peptide. Journal of Biomolecular NMR 18, 371-372 (2000).  PMID: 11200536

1.   Dhalluin C, Yan KS, Plotnikova O, Lee KW, Zeng L, Kuti M, Mujtaba S, Goldfarb MP & Zhou MM. Structural Basis of SNT PTB Domain Interactions with Distinct Neurotrophic Receptors. Molecular Cell, 6, 921-929 (2000).  PMID: 11090629

Locations

CUMC/Herbert Irving Pavilion

161 Fort Washington Avenue
Suite 862
New York, NY 10032

Phone: (212) 305-1021

Get Directions


Assistant Professor of Medicine

  • 2017             ASCI Young Physician-Scientist Award, American Society for Clinical Investigation
  • 2017-2020    Louis V. Gerstner, Jr. Scholars Award, Columbia University Medical Center
  • 2013             MSC 2013 Travel Award, Case Western Reserve School of Medicine
  • 2013             Gregory J. Gurtner Memorial Lecturer in GI, Washington University School of Medicine
  • 2012-2017    Career Award for Medical Scientists, Burroughs Wellcome Fund
  • 2012-2017    K08 Mentored Clinical Scientist Career Development Award, NIDDK
  • 2009-2012    MD Scholar, California Institute for Regenerative Medicine (CIRM), Stanford University
  • 2006             Glasgow-Rubin Achievement Award, American Medical Women’s Association
  • 1997-2006    Medical Scientist Training Program, Mount Sinai School of Medicine
  • 2004             Basic Science Academic Achievement Award, Mount Sinai School of Medicine
  • 2004             Best Doctoral Dissertation Prize, Mount Sinai School of Medicine
  • 1997-1998    Fanny Bullock-Workman Graduate Fellowship