Endocrinology, Diabetes and Metabolism 

Research

The Division of Pediatric Endocrinology, Diabetes and Metabolism is involved in clinical and basic research in the areas of metabolic bone disease, growth and adrenal disorders, and insulin signaling and pathogenesis of diabetes. Projects include:

  • diabetes-related research
  • investigations of factors involved in bone development
  • studies of vitamin D deficiency and its relationship to obesity and insulin-resistant individuals

Our research has been funded by National Institutes of Health grants and several of our faculty and fellows have received awards for their work.

Basic Research Program

The goal of the Laboratory of Pediatric Endocrinology, led by Maria Vogiatzi, MD, is the study of diseases which affect bone development and accrual. We want to determine the mechanisms by which environmental factors as well as chronic disease states may impact on the development of abnormal bone mass in children and adolescents. During childhood and adolescence, bone is deposited so that the skeleton grows in both size and density to reach a peak bone mass in early adulthood. Suboptimal peak bone mass may lead to osteoporosis and lifelong increased risk for fractures.

One focus of our research is to understand the mechanisms by which hematological conditions, such as thalassemia, lead to the development of low bone mass. Research efforts at the moment focus on elucidating the molecular mechanism that regulate bone turnover during ineffective erythropoiesis and the development of novel therapies to treat low bone mass in these disorders.

In addition, the Division of Endocrinology, Diabetes and Metabolism has developed successful collaborations with many laboratories of Weill Cornell and tri-institutional campus on such topics as:

  • insulin resistance, looking at insulin signaling and glucose trafficking
  • efficacy of novel therapies for osteogenesis imperfecta
  • endocrinopathies related to iron overload
Clinical Research Program

Researchers in the Division of Pediatric Endocrinology, Diabetes and Metabolism are currently conducting a number of studies including:

Studies on obesity/insulin resistance: Our current studies include community school-based research programs that focus on nutritional counseling and lifestyle modification. Our faculty wants to determine changes on the cardiovascular profile of participating children, and therefore, determine the benefits derived from these interventions.

Metabolic bone studies: These studies examine the relationship of vitamin D concentrations with bone turnover in pediatrics. Additional studies focus on the role of vitamin D as a modifier of insulin sensitivity in obesity. Finally, we are also interested in determining the factors that lead to increased fracture risk in pediatric populations.

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Division of Pediatric Endocrinology
505 East 70th Street
Helmsley Tower, 3rd Floor
New York, NY 10021

Phone: (646) 962-2116
Fax: (646) 962-0265

To schedule an appointment with one of our physicians, or to schedule an endocrine test, please call us during office hours and one of our staff will assist you.

Office Hours: Monday through Friday, 9 am to 5 pm

For office hours and staff information, view our medical practice page.